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1、山東輕工業(yè)學院2012屆本科畢業(yè)設計(論文)摘要本設計采用濕法制粒壓片，主要生產工序為粉碎、篩分、混合、制粒、干燥、壓片、包衣、包裝。然后根據(jù)生產工序進行物料衡算與能量衡算。物料衡算應考慮到每一步生產工序產生的損失，從最后一步開始，往前面的工序推進來進行計算。物料衡算確定了原材料消耗定額，從而確定了設備工藝設計與選型，進而決定管路設計等各種設計項目。再者就是能量衡算，涉及到生產工序中的干燥及冷卻需要消耗循環(huán)水的熱量。能量衡算還包括每臺設備在生產中消耗的電能。選擇廠址時，周圍應有良好的衛(wèi)生環(huán)境，空氣污染少，無水土污染的地區(qū)，也
2、要盡量避免人流，物流比較密集的工業(yè)區(qū)域。廠址的交通運輸應方便、快捷，水，電汽，原材料和燃料的供應要方便。車間應按工藝流程合理布局，有利于生產操作，并能保證對生產過程進行有效的管理。正確劃分生產工藝流程中生產區(qū)域的潔凈級別，避免生產流程的迂回和人、物流交叉等。制藥用水的制備以飲用為原料，經逐級提純水質。最后應做好廠區(qū)及車間的安全衛(wèi)生工作，并處理好生產過程中產生的“三廢”。關鍵詞：拉莫三嗪工藝設計工藝流程片劑生產AbstractThedesignusesthewetgranulationtotablet,themainprodu
3、ctionprocessescontaincrushing,sieving,mixing,granulating,drying,pressing,coatingandpackaging.Theconsiderationofthematerialbalanceandtheenergybalanceisdependontheproductionprocess.Materialbalanceconsiderationshouldbecalculatedfromthelaststeptotheformer,takingintoacc
4、ountofeachstepoflossineveryproductionprocesses.Materialbalancecalculationdeterminestherawmaterialconsumptionquota,theprocessdesignandselectionofequipment,soasthepipelinedesignandotherdesignprojects.Furthermore,relatedtothedryingandcoolingoftheproductionprocess,thee
5、nergybalanceshouldconsumeheatconsumptionofthecirculatingwater.Energybalancealsoincludestheelectricenergyconsumptionofeachequipmentintheproduction.Thesurroundingenvironmentshouldbefavorable,havinglessairpollutionandnosoilpollution,avoidingindustrialareathatpeopleand
6、materialsintensivewhenchoosingthelocationofafactory.Thesiteshouldbeconvenient,applyingadequatewater,electricity,steamandrawmaterials.Thearrangementofworkplaceshouldbesuitableonthebasisoftheprocess,facilitatethe32山東輕工業(yè)學院2012屆本科畢業(yè)設計(論文)productionoperation,andcanguara
7、nteetheeffectivemanagementtotheproductionprocess,correctlydividingproductionprocessproductionareacleanlevel,avoidingtheproductionprogressroundabout,peopleandlogisticscrossover.Thedrinkingwaterisusedastherawmaterialforthehepreparationofpharmaceuticalwater,throughste
8、pwiseprocesstopurifythewaterquality.Finally,itshouldhandlethesafetyandhealthoffactoryandworkplace,anddealwiththe"threewastes"intheproductionproce
