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《濾泡性輔助t細(xì)胞及濾泡性調(diào)節(jié)t細(xì)胞在結(jié)直腸癌患者外周血中的表達(dá)及其臨床意義》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、授予單位代碼10089學(xué)號(hào)或申請(qǐng)?zhí)?0123188HebeiMedicalUniversity碩士學(xué)位論文專業(yè)學(xué)位濾泡性輔助T細(xì)胞及濾泡性調(diào)節(jié)T細(xì)胞在結(jié)直腸癌患者外周血中的表達(dá)及其臨床意義研究生：趙召龍導(dǎo)師：李中信教授專業(yè)：外科學(xué)2015年3月河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識(shí)產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師（或指導(dǎo)小組）的指導(dǎo)下，由本人獨(dú)立完成。本學(xué)位論文研究所獲得的研究成果，其知識(shí)產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對(duì)本學(xué)位論文進(jìn)行交流、公開和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文，第一署名為單位河北醫(yī)科大學(xué)
2、，試驗(yàn)材料、原始數(shù)據(jù)、申報(bào)的專利等知識(shí)產(chǎn)權(quán)均歸河北醫(yī)科大學(xué)所有。否則，承擔(dān)相應(yīng)法律責(zé)任。研究生簽名左導(dǎo)師簽章:t二級(jí)學(xué)院領(lǐng)導(dǎo)蓋章：>/淨(jìng))?驗(yàn)臺(tái),河北醫(yī)科大學(xué)研究生學(xué)位論文獨(dú)創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研宄成果，除了文中特別加以標(biāo)注和致謝等內(nèi)容外，文中不包含其他人己經(jīng)發(fā)表或撰寫的研究成果，指導(dǎo)教師對(duì)此進(jìn)行了審定。本論文由本人獨(dú)立撰寫，文責(zé)自負(fù)。研宄生簽名:導(dǎo)師簽章月7SX0日l(shuí)o)S目錄中文摘要··················································
3、·······························1英文摘要·················································································4英文縮寫·················································································8研究論文濾泡性輔助T細(xì)胞及濾泡性調(diào)節(jié)T細(xì)胞在結(jié)直腸癌患者外周血中的表達(dá)及其臨床意義前言·············
4、····································································9材料與方法······································································10結(jié)果···············································································13附圖·····························
5、··················································15附表···············································································20討論···············································································21結(jié)論········································
6、·······································24參考文獻(xiàn)·········································································25綜述濾泡性輔助T細(xì)胞（Tfh）與人相關(guān)疾病的研究·················30致謝·····················································································53個(gè)人簡(jiǎn)歷····
7、···········································································54中文摘要濾泡性輔助T細(xì)胞及濾泡性調(diào)節(jié)T細(xì)胞在結(jié)直腸癌患者外周血中的表達(dá)及其臨床意義摘要背景：結(jié)直腸癌是全世界發(fā)病率排名第三的惡性腫瘤，每年有超過100萬(wàn)患者確診為結(jié)直腸癌。傳統(tǒng)治療手段（手術(shù)，化療，放療，靶向治療）療效不理想。除了腫瘤本身的機(jī)制外，腫瘤微環(huán)境特別是炎癥反應(yīng)、免疫反應(yīng)與腫瘤的進(jìn)展甚至放化療、靶向藥物抵抗有關(guān)?？梢哉f,腫瘤免疫治療的時(shí)代已經(jīng)到來。事實(shí)上
8、越來越多的證據(jù)表明,在預(yù)防腫瘤的發(fā)生、生長(zhǎng)和轉(zhuǎn)移擴(kuò)散中免疫系統(tǒng)扮演重要的角色。+對(duì)于CD4T淋巴細(xì)胞亞群的研究是近年來免疫學(xué)研究的一個(gè)熱點(diǎn)。+Tfh作為CD4T淋巴細(xì)胞亞群的一種，是近年來研究發(fā)現(xiàn)的一種特殊的輔助性T細(xì)胞，表達(dá)CXCR5的Tfh細(xì)胞在CXCL13的趨化下，被募集到淋巴濾泡，參與誘導(dǎo)B細(xì)胞的分化及生發(fā)中心的形成，通過產(chǎn)生IL-21等細(xì)胞因子以及
