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1、現(xiàn)代藥物與臨床Drugs&Clinic第29卷第4期2014年4月·363·夏黃顆粒提取浸膏粉的粉體學(xué)和穩(wěn)定性研究1,2,32,32,3*1,2,3肖瑞穎，廖茂梁，張鐵軍，胡喬1.天津中醫(yī)藥大學(xué)，天津3001932.天津藥物研究院釋藥技術(shù)與藥物代謝動力學(xué)國家重點實驗室，天津3001933.天津藥物研究院中藥現(xiàn)代制劑與中藥質(zhì)量控制技術(shù)國家和地方工程實驗室，天津300193摘要：目的對夏黃顆粒提取浸膏粉進行處方前粉體學(xué)和穩(wěn)定性研究，為設(shè)計優(yōu)良的顆粒制劑處方提供參考。方法考察夏黃顆粒提取浸膏粉的主要粉體學(xué)參數(shù)，如堆密度、休止
2、角、溶化性、pH值、吸濕性、臨界相對濕度。以主要活性成分蘆薈苷為指標(biāo)，考察高溫、高濕和強光照射的影響。結(jié)果夏黃顆粒提取浸膏粉流動性較差，休止角大于45°，水溶性較好，呈弱酸性，臨界相對濕度為72%；不耐高溫，易吸濕，不耐光照。結(jié)論夏黃顆粒提取浸膏粉應(yīng)在密封、避光、干燥處儲存。關(guān)鍵詞：夏黃顆粒提取浸膏粉；粉體學(xué)；穩(wěn)定性中圖分類號：R283.6文獻標(biāo)志碼：A文章編號：1674-5515(2014)04-0363-04DOI:10.7501/j.issn.1674-5515.2014.04.008Micromeritican
3、dstabilitystudiesonXiahuangGranuleextracts1,2,32,32,31,2,3XIAORui-ying,LIAOMao-liang,ZHANGTie-jun,HUQiao1.TianjinUniversityofTraditionalChineseMedicine,Tianjin300193,China2.StateKeyLaboratoryofDrugDeliveryTechnologiesandDrugMetabolism,TianjinInstituteofPharmaceu
4、ticalResearch,Tianjin300193,China3.TheNationalandLocalEngineeringLaboratoryoftheModernizedChineseMedicineandChineseMedicineQualityControlTechniques,TianjinInstituteofPharmaceuticalResearch,Tianjin300193,ChinaAbstract:ObjectiveToevaluatethepreformulationstudies,s
5、uchasmicromeriticandstabilitystudiesonXiahuangGranuleextractsandtoprovideareferenceforthedesignoffineparticleformulationofdesign.MethodsPowdermicromeriticsmajorparametersofXiahuangGranuleextracts,suchasbulkdensity,angleofrepose,dissolveresistance,pHvalue,moistur
6、eabsorption,andcriticalrelativehumiditywerestudied.Aloinasthemainactiveingredientintheprescriptionwasdeterminedtocomparetheeffectsofhightemperature,highhumidity,andstronglightonXiahuangGranuleextract,suchasbulkdensity,angleofrepose,dissolveresistance,pHvalue,moi
7、stureabsorption,andcriticalrelativehumiditywerestudied.ResultsXiahuangGranuleextractshadthegoodwatersolubilitywithreposeanglegreaterthan45degrees,butpoormobilityandweakacidity.Thecriticalrelativemoistureofitwas72%.XiahuangGranuleextractshadnotbeenresistanttohigh
8、temperature,moistureabsorption,andlightfastproperties.ConclusionThepowderofXiahuangGranuleextractsshouldbestoreduponsealed,dark,anddryplace.Keywords:XiahuangGranuleex
