子癇前期患者胎盤組織中pdgfa的表達及意義

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1、子癇前期患者胎盤組織中PDGFA的表達及意義作者：高學印,薛瑞敏,鄭秀玲,郭影,吉增良單位：055250河北省巨鹿縣醫(yī)院婦產(chǎn)科(高學印、薛瑞敏、鄭秀玲、吉增良);河北醫(yī)科大學第三醫(yī)院婦產(chǎn)科(郭影)【摘要】目的通過觀察子癇前期患者胎盤組織血小板源性生長因子A(PDGFA)的表達，探討子癇前期發(fā)病機制。方法采用HE染色觀察胎盤形態(tài)學病理變化，免疫組化法測定39例子癇前期患者及20例正常晚孕婦女胎盤組織中PDGFA的表達強度。結(jié)果(1)HE染色顯示正常孕足月胎盤絨毛和輕度子癇前期胎盤絨毛中滋養(yǎng)細胞以合體滋養(yǎng)細胞為主，而重度子癇前期胎盤絨毛中細胞滋養(yǎng)細胞明顯增生

2、，絨毛大部分不成熟，胎盤蛻膜間質(zhì)細胞呈大小不等塊狀、桿狀，蛻膜血管內(nèi)皮細胞纖維化，蛻膜纖維素性壞死也明顯增多。(2)重度子癇前期組PDGFA表達強度較正常妊娠組、輕度子癇前期組明顯升高(P<0.05)，而PDGFA表達強度在正常妊娠組、輕度子癇前期組差異無統(tǒng)計學意義(P>0.05)。結(jié)論重度子癇前期患者胎盤形態(tài)學病理變化明顯，且與病情嚴重程度呈平行關(guān)系。PDGFA由胎盤產(chǎn)生，并參與了妊娠期高血壓疾病的病理生理過程。【關(guān)鍵詞】妊娠期高血壓疾病;血小板源性生長因子A;胎盤組織ExpressionandsignificanceofPDGFAinp

3、lacentafrompatientswithpre-eclampsiaGAOXueyin,XUERuimin,ZHENGXiuling,etal.DepartmentofGynecologyandObstetrics,JuluCuntryHospital,Hebei,Julu055250,China【Abstract】ObjectiveToobservethechangesofplateletderivedgrowthfactor(PDGFA)inpatientswithpreeclampsiatoexploreitspathogenesis.Metho

4、dsTheexpressionlevelsofPDGFAinplacentaof39patientswithpreeclampsiaand20normallatepregnantwomenweredetectedbyimmunohistochemstryandHEstaining.Results(1)Theplacentalvillusincontrolgroupandmildpreeclampsiagroupwerecharacterizedbydominantsyneytiotrophoblastcells,however,theplacentalvi

5、lllusinseverepreeclampsiagroupwerecharacterizedbycytotrophoblasticcellsproliferating,basementmembranethickening,syncytiotrophoblastknottingincreasing,synchtiotrophoblastbudding.(2)ThepositiveexpressionratesofPDGFAincontrolgroup,mildpreeclampsiagroupandseverepreeclampsiagroupwere3

6、8.89%,44.97%and76.54%respectively.Therewasasignificantdifferencebetweenmildandseverepreeclampsiagroup(P<0.05),buttherewasnodifferencebetweencontrolgroupandmildpreeclampsiagroup(P>0.05).ConclusionThepathologicalchangesofplacentaareparalleledwiththeseverityofpreeclampsia，whic

7、hindicatesthattheplacentalpathologicalchangesplayanimportantroleinthedevelopmentofseverepreeclampsia.TheexpressionofPDGFAmaybeinvolvedinthepathophysiologicalprocessofhypertensioningestationalperiod.【Keywords】hypertensioningestationalperiod;plateletderivedgrowthfactorA;placenta妊娠期

8、高血壓疾病(hypert