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1、嗎啡對垂體后葉素致兔心肌損傷的影響【摘要】目的觀察嗎啡預(yù)處理垂體后葉素引起的兔心肌損傷后血壓、心電圖和血清心肌肌鈣蛋白I(cTn-I)的含量變化，并觀察心肌病理切片，探討嗎啡對受損心肌預(yù)處理的影響。方法將成年中國白兔24只隨機分為三組，對照假手術(shù)組(A組)，手術(shù)模型完成穩(wěn)定45min后予0.9%生理鹽水0.2～0.3mL/kg，30s靜脈注射完畢；藥物損傷心肌組(B組)，45min后予垂體后葉素(2.5U/kg)0.2～0.3mL/kg，30s注射完畢；嗎啡預(yù)處理組(C組)，予嗎啡0.65mg/kg靜脈推注，45min后予垂
2、體后葉素(2.5U/kg)0.2～0.3mL/kg，30s注射完畢，記錄給藥前后平均動脈壓(MAP)、中心靜脈壓(CVP)、HR及T波變化；測定血清cTn-I含量；觀察給藥48h后白兔心肌組織的變化。結(jié)果與A組比較，B組MAP、CVP、T波明顯升高(P＜0.01)，HR明顯下降(P＜0.01)；與B組相比，C組MAP、CVP、T波明顯下降(P＜0.01)，T波B、C組明顯高于A組(P＜0.01)。血清cTn-I水平A、C組低于B組(P＜0.01)。結(jié)論嗎啡預(yù)處理對垂體后葉素所致的兔心肌損傷有保護作用?！娟P(guān)鍵詞】心肌損傷；嗎啡
3、；肌鈣蛋白I；雙抗夾心免疫吸附法；兔 Abstract:ObjectiveToobservethechangeofbloodpressure,electrocardipgramandTroponinIaftermorphinepretreatmentonacutemyoardialinfarctioninducedbypituitrininrabbits,andtocomparethemwiththechangeofpathostaining,andtoexploretheeffectofmorphinepretreatm
4、entonacutemyocardialischemicinjury.MethodsTwenty-fourrabbitsweredividedrandomlyintothreegroups:controlgroup(GroupA),pituitringroup(GroupB)andmorphinepretreatmentgroup(GroupC).TheinformationincludedMAP、CVP、HRandTwavewereobservedandrecordedatdifferenttimepoints.Itwas
5、dividedintotwoobservingphrasesof24h,48handdeterminedthecontentsofbloodserumcTn-Iandcaridiacpathostainof48h.Results(1)Changesinmyocardiacmechanics:myocardiacmechanicshadadynamicchangeafterinjectionofpituitrin2.5U/kgweight.parametersbetweenandwithingroupsthroughoutth
6、eexperimentalperiodexceptischemiagroup,whichhadasignificantlreductioninHRandasignificantincreaseinMAP,CVPandTwave.Comaredwithothergroups.GroupCcomparedwithGroupA,MAPandCVPateachtimepointtherewasnosignificantstatisticaldifference,HR(1min)decreased(P＜0.05),Twaveincre
7、ased(P＜0.01).ComparedBgroupwithgroupA,MAP(1min)significantlyincreased(P＜0.01),CVPsignificantlyincreasedfrom15secto5min(P＜0.01),HRsignificantlyloweredin15secto10min(P＜0.01),Twavesignificantlyincreased(P＜0.01).ComparedGroupBwithCgroup,HRsignificantlydecreasedatthepoi
8、ntoffrom30secto2min(P＜0.01),MAP,CVPandTwavewasnosignificantstatisticaldifferenceatdiffernettimepoints.(2)BloodserumcTn-Ishowedsignificantdifferen
