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1、中國(guó)組織工程研究與臨床康復(fù)第73謄勞29200907—16出版JournalofClinicalRehabilitative~ssueEngineeringResearchJuly16,2009Vo1.73,No.29翟震8asicEx。er_memNano-hydroxyapatite,COIIagencompositedwithrecombinanthumanbonemorphogenetiCprotein·2andtitaniummembraneinrepairingperipheralbonedef
2、ectsofinstantdentalimplants☆LiuBing’ChenPeng,WangZhong.yi。KeJie’LiXiao—hua’WangZheng—wen’,,,,AbstractBACKGROUND:Recently.withtherapiddevelopmentofmateriaIscienceandbioscience.thetechnologyofdentalimplanthasDepartmentofStomatology,madegreatprogress,especial
3、lytheimmediateimplanttechnologyButthesizeandshapeofimplantareusualynotfitfortoothChinesePLAextractionwound.soitisanimportantfactorthatleadstofailurewhenimplantandtoothextractionwoundcannotformcloseGenera1HospitaloftangencyGuidedboneregenerationorbonegrafti
4、ngmaterialsareusuallyusedtosolvethisproblemAirForceBeijing100036,China:0BJECTlVE:Tostudytheeffectsofnano—hydroxyapatite/collogen(nHAC)withrecombinanthumanbonemorphogeneticDepartmentofOraIandMaxilofaciaJprotein一2(rhBMP一2)andtitanium(Ti)membraneonrepairingpe
5、ripheralbonedefectsofinstantimplantSurgery,ChineseDESIGN.TIMEANDSETTING:Arandomized.controledanimaIstudywasperformedattheCentralLaboratory.theFourthPLAGeneraIMilitaryMedicaIUniversityofChinesePLAbetweenJanuary2005andJanuary2006Hospital,Beijing100853.China;
6、MATERIALS:Tiscrewimplants(diameter2mm,length10mm,andpitch04mm)withoutthepartthatwentthroughgumwereDepartmentofoferedbyNonferrousMetalAcademyinBaoii.China.ThenonabsorbabIeTimembranes(2cmx2cm)wereoferedbyPrOsth0dOnticsZhongbangBiomaterialLimitedCompanyinXi’a
7、n,China,ThenHACmaterialsweregiftedbyprofessorCuiFu-zhaifromMaterialStomatologyHospital,F(xiàn)ourthScienceandEngineeringDepartmentofTsinghuaUniversityandfabricatedinto05mmx0.5mmx05mmsmallblocks.rhBMP2MilitaryMedicalwasoferedbytheAcademyofMilitaryMedicaISciencesi
8、nBeijing.China.rhBMP一2wasdissolvedwithhydrochloriccarbamidineUniversityofChinesePLAXi’anandthennHACwasimmersedinitVacuumizationfreeze.drying.a(chǎn)ndEkibondegermationwerefoIlowedEachgramofnHAC710032ShaanxIcompound