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1、UrticariaCHENAijunMDDepartmentofDematology,TheFirstAffiliatedHospital,ChongqingMedicalUniversityDefinitionUrticariaisaverycommondiseaseandisavascularreactionoftheskincharacterizedbytheappearanceofwheals,whiteorredevanescentplaquesgenerallysurroundedby
2、aredhaloorflareandassociatedwithsevereitching,stinging,orprickingsensations.Thesearewheals,whiteorredevanescentplaquesgenerallysurroundedbyaredhaloorflare.Fastappearinganddiminishing,notraceafterdiminishing.EtiologyFoodsMedicinesInfectionsPhysicalfact
3、orsAnimalsandplantsSpiritfactorsDiseasesofinternalorgansEtiology1.FoodsThemostallergenicfoodsareshellfish,shrimps,crab,chocolate,nuts,peanuts,tomatoes,strawberries,melons,pork,cheese,garlic,onions,andspices.Eggsandmilkalwaysinduceurticariainchildren.2
4、.MedicinesManymedicinescanstarturticariabyallergy,themostcommondrugsareasfollows:penicillin,serum,vaccine,furazolidone,sulfanilamideandsoon.Sometimesafewdrugscandirectlystimulatemastcellstoproducehistamine,likeaspirin,morphine,codeine,quinine,etc.3.In
5、fectionsInfectionscausedbyallorganismsareanotherpossiblereasonstoinduceurticaria.Themostcommonorganismisvirusofupperrespiratoryandstaphylococcusaureus.Chronicinfectionsofthepatientscannotbeeasyverifiedasthepathogenofurticaria;itmustbetestedbytherapy.4
6、.Physicalfactors:Cold,hot,sunlight,frictionandpressure5.Animalsandplants:Urticariacanbeinducedbyanimal'sfurskinorpollenorstingingofinsects.6.Spiritfactors:Insomecases,stresscantriggerurticaria,butinanothercasesstressmayleadtohistaminereleasing.7.Disea
7、sesofinternalorgansRheumaticdisorder,rheumatoidarthritis,systemiclupuserythema,malignanttumor,disorderofendocrineandsomeotherscanbeanotherreasonsofurticaria.Pathogenesis1.AllergyanaphylactictypeimmunecomplextypeandallergicvasculitisThewhealresultsfrom
8、increasedcapillarypermeability,whichallowsproteinsandfluidstoextravasate.Capillarypermeabilityresultsfromtheincreasedreleaseofhistaminefromthemastcellssituatedaroundthecapillaries.AllergyThemastcellistheprimaryeffectorcellinurticarialreactions
