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1、WangQZ,etal./NeuralRegenerationResearch.2013;8(35):3353-3358.Differentiationofhumanadipose-derivedstemcellsintoneuron-likecellsbyRadixAngelicaeSinensis**QiaozhiWang1,LileZhou1,YongGuo1,GuangyiLiu1,JiyanCheng2,HongYu11DepartmentofHistologyandEmbryology,LuzhouMedicalCollege,Luzhou646000
2、,SichuanProvince,China2DepartmentofElectronicMicroscopy,LuzhouMedicalCollege,Luzhou646000,SichuanProvince,ChinaQiaozhiWang,Master,Associateprofessor.Correspondingauthor:HongYu,Master,Professor,DepartmentofHistologyandEmbryology,LuzhouMedicalCollege,Luzhou646000,SichuanProvince,China,y
3、uhong8592@126.com.Received:2013-07-16Accepted:2013-09-20(N20111231001)Funding:ThisstudywasfinanciallysupportedbytheScienceandTechnologyProjectofSichuanProvince,No.2009JY0128andtheHealthMinistryofSichuanProvinceinChina,No.20060052.Authorcontributions:WangQZandZhouLLperformedthemajority
4、ofexperiments.GuoY,LiuGYandChengJYconductedtheexperimentsandanalyzedthedata.WangQZwrotethemanuscript.YuHprovidedfinancialsupport,designedthestudyandrevisedthemanuscript.Allauthorsapprovedthefinalversionofthepaper.Conflictsofinterest:Nonedeclared.Authorstatements:Themanuscriptisorigina
5、l,hasnotbeensubmittedtoorisnotunderconsiderationbyanotherpublication,hasnotbeenpreviouslypublishedinanylanguageoranyform,includingelectronic,andcontainsnodisclosureofconfidentialinformationorauthorship/patentapplication/fundingsourcedisputations.ResearchHighlights(1)RadixAngelicaeSine
6、nsis,whichhasantioxidanteffectsandnoknowntoxicity,isusedasaninducertopromoteadipose-derivedstemcelldifferentiationintoneuron-likecells.(2)TheresultsshowthatnotonlycanRadixAngelicaeSinensisinducedifferentiationofhumanadipose-derivedstemcellsintoneuron-likecells,itcanalsoincreasetheirsu
7、rvivalrate,thusopeningupnewideasforoptimalinductionmethodsofstemcells.AbstractHumanadiposetissuesareanidealsourceofstemcells.Itisimportanttofindinducersthatcansafelyandeffectivelydifferentiatestemcellsintofunctionalneuronsforclinicaluse.Inthisstudy,weinvestigatetheuseofRadixAngelicaeS
8、inens
