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1、Stroke.2016Aug;47(8)2016-8-18QuanDongBackgroundIntracerebralhemorrhage(ICH)isthemostseriouscomplicationofintravenousthrombolysiswithrecombinanttissue-typeplasminogenactivator(IV-r-tPA)inpatientswithischemicstroke.RemoteParenchymalHemorrhages（rPH）hasanincidenc
2、eof1.3to3.7%andisassociatedwithapooroutcomeLittleisknownaboutthefrequency,associatedriskfactors,andprognosisofrPH. Theaimofthisstudywastoanalyzefrequency,riskfactors,clinicalandradiologicalfeatures,andprognosisofpatientswithrPH.MethodsMethods(StudyPopulation)
3、Methods(ClinicalAssessment)Thefollowingvariableswererecorded:DemographicstraditionalvascularriskfactorsliverdiseasepreviousmedicationtimefromtheonsetofsymptomstotheadministrationofIV-r-tPANIHSSscoreatadmissionand24to36hourshypertensiveepisodesandhyperthermia;
4、baselinelaboratorydatatypeofhemorrhagiccomplication,numberandlocalizationrPH;TOASTsymptomaticICHfunctionaloutcomeandmortalitywereassessedat3months(Rankinscalescore≤2).人口學(xué)特征血管危險因素肝臟疾病既往用藥溶栓時間NIHSS評分血壓及體溫基線實驗室數(shù)據(jù)出血并發(fā)癥類型，rPH部位和數(shù)量TOAST分型癥狀性腦出血功能預(yù)后Methods(Radiologi
5、calAssessment)MRI1.5TT1T2FLAIRT2*DWIRSI（recentsilentischemia）LeukoaraiosisCMB（cerebralmicrobleeds）CSS（corticalsuperficialsiderosis）VascularmalformationsMethods(StatisticalAnalysis)ischemicstrokeIV-r-tPArPHgroupSingleormultiplerPHrPH+concomitantPHPHgroupwithou
6、tanyrPHorPHNobleedingindicateshemorrhagicinfarctMethods(StatisticalAnalysis)StatisticalAnalysiscontingencytableswiththeχ2ortheFisherexacttestStudentttestforquantitativevariablesMann–WhitneyUtestmultiplelogisticregressionanalysisResultsDistributionofBleedingCo
7、mplicationsRiskFactorsClinicalandRadiologicalFeaturesRiskFactorsintheWholeSampleDemographicvariables,traditionalvascularriskfactors,previoustreatments,timefromtheonsetofsymptomstotheadministrationofIV-r-tPA,initialNIHSSscore,vitalsigns,laboratoryfindings,andp
8、athogenesiswerenotdifferentbetweenpatientswithrPHandthosewithoutanyrPHorPHRiskFactorsinPatientsWithMRIPrognosisDiscussionQ:frequencyInthismulticenterstudy,weobservedthat3.4%patientshadarP
