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1、Haloperidol藥物名稱:氟哌啶醇化學(xué)名:1-(4-氟苯基)_4-(4-(4-氯苯基)-4-羥基-1-哌啶基〕-1-丁酮結(jié)構(gòu)式:CII適應(yīng)癥:①各種急、慢性精神分裂癥。②焦慮性神經(jīng)癥。③兒童抽動-穢語綜合征,乂稱TOureUe綜合征(TS),小劑量木品治療有效,能消除不自主的運(yùn)動,又能減輕和消除伴存的精神癥狀。④嘔吐及頑固性呃逆。SDBS-MassSDBS—MassMS-IW-9284SUBSNO.140244—(4—C.p—cKloropKenyl)-4—Kydroxypiperidino)-4—£luorobutyropKenon
2、eC21H23CLF1I02(Masso£molecularion:375)1OO150200250m/zxllsssaAIPPy300SourceTemperature:170°CSampleTemperature::180°CDIRECT,75eVIRHIT—HO番7189
3、5C0REwIJ1SOBS一MO^1冬024
4、IR一N丨DA—613兮2;KBRD3SC4<4-(P-CHLOROPHENYLI-4-HYOROXYPIPERIDINO1-4?-FLUOROBU7YROPHEMONCtooI3M4MOKOOO3129GS29^857
5、2955?M2917GO2fi39422fl2437169241401M?JI4&6Ml17299216244Gs45I3G939I3L4S7l?SS,5l?44I23S3Q12241*91199吻3use1211312SlJ104710874?104?1019441006609se3543dMTT9962742S754642500-o-rKrCMa-CHa--OMjooCl13CNMRSDBS-13CUMRSDBSHo.14024CDS-08-299C21H23ClFN024一(4—(p—chlorophenyl)—4—hydroxy
6、pipexidino)—4*luorobutyrophenone160140120loo80604020198.074381126.5610008167.15114F2115.59468E9162.15121F2115.17482F9149.01446369.3655710133.82231F457.1141411133.76223F448.7378512130.75488F537.6380013130.56773F535.5245714621.8842515127.489757JHNMRII7I54ISDBS-^NMRSDBSNo.140
7、24HSP-43-188c21h23Clfn024-(4-(p-chlorophenyl)—4-hydroxypiperidino)-4"-fluorobutyrophenone9ClHAssign.Shift(ppm)A8.085G2.582B本l7.37J2.360C7.36K2.34D7.34Ll.85lE4.85Ml.674E2.982Nl.476Shift(ppm)Assign.J(F-l9,A)=5.6HZJ(F-l9,C):9.0HZ