icu膿毒癥患者t淋巴細(xì)胞亞群、調(diào)節(jié)性t細(xì)胞檢測的臨床意義

icu膿毒癥患者t淋巴細(xì)胞亞群、調(diào)節(jié)性t細(xì)胞檢測的臨床意義

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1、授予單位代碼10089學(xué)號或申請?zhí)?0153550中國圖書分類號R631+.3HebeiMedicalUniversity碩士學(xué)位論文專業(yè)學(xué)位ICU膿毒癥患者T淋巴細(xì)胞亞群、調(diào)節(jié)性T細(xì)胞檢測的臨床意義研究生:杜蕊導(dǎo)師:楊秀芬教授專業(yè):急診醫(yī)學(xué)二級學(xué)院:河北醫(yī)科大學(xué)第一醫(yī)院2018年3月目錄中文摘要············································································································1英文摘要·········

2、···································································································3英文縮寫············································································································5研究論文ICU膿毒癥患者T淋巴細(xì)胞亞群、Treg細(xì)胞檢測的臨床意義前言·······················

3、·····················································································7材料與方法······························································································9結(jié)果···················································································

4、······················11附圖··········································································································14附表··········································································································16討論·························

5、·················································································19結(jié)論··········································································································22參考文獻(xiàn)··········································································

6、························22綜述調(diào)節(jié)性T淋巴細(xì)胞亞群與膿毒癥的研究進(jìn)展·································26致謝············································································································34個(gè)人簡歷·········································································

7、································35中文摘要ICU膿毒癥患者T淋巴細(xì)胞亞群、調(diào)節(jié)性T細(xì)胞檢測的臨床意義摘要目的:近年來研究發(fā)現(xiàn),免疫紊亂在膿毒癥發(fā)病的發(fā)生發(fā)展中起重要作用?,F(xiàn)有的研究證實(shí),在膿毒癥發(fā)病發(fā)展過程中,伴隨著T淋巴細(xì)胞亞群的變化,且與預(yù)后相關(guān)。隨著對膿毒癥發(fā)病機(jī)制研究的深入,調(diào)節(jié)性T淋巴細(xì)胞在疾病發(fā)展中所起的作用越來越被重視。但大多數(shù)研究多集中在動物實(shí)驗(yàn)上,臨床上對調(diào)節(jié)性T淋巴細(xì)胞的研究尚不多。同時(shí)關(guān)于T淋巴細(xì)胞亞群與Treg細(xì)胞(調(diào)節(jié)性T淋巴細(xì)胞)的研究鮮有報(bào)道,因此,本研究旨在探討T淋巴細(xì)胞

8、亞群與調(diào)節(jié)性T淋巴細(xì)胞水平在膿毒癥疾病發(fā)展過程中的變化,進(jìn)一步闡明在膿毒癥發(fā)病過程中的免疫機(jī)制,為評價(jià)膿毒癥病情程度及預(yù)后開辟新的臨床途徑。方法:選取2017年5月到2017年11月入住重癥監(jiān)護(hù)室(ICU)

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