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1、普濟痔瘡栓用于混合痔術(shù)后臨床觀察王海霞山西醫(yī)科大學(xué)附屬第二醫(yī)院中藥房摘要：目的探討普濟痔瘡栓治療混合痔術(shù)后的有效性、安全性及對炎癥和生活質(zhì)量的影響。方法91例混合痔術(shù)后患者隨機分為對照組45例和觀察組46例，對照組予復(fù)方荊芥熏洗劑和肛泰栓，觀察組予復(fù)方荊芥熏洗劑和普濟痔瘡栓治療。比較水腫消退時間、疼痛消退時間、創(chuàng)而愈合時間、臨床療效和不良反應(yīng)，ELISA法測定IL-6、1L-8和TNF-u，采用SF-36量表評價生活質(zhì)量。結(jié)果觀察組疼痛消退時間、水腫消退時間及創(chuàng)面愈合時間分別為(9.10±1.37)d、(6.68±1.14)d和(14.17±3.32)d，短于對照組的(12.45±3.1
2、7)d、(8.04±1.23)d和(18.16土3.02)d;觀察組總有效率為87.0%,高于對照組的68.9%;觀察組術(shù)后1周血清IL-6、IL-8和TNF-(i顯著低于對照組，SF-36量表中生理功能、軀體疼痛、活力及精神健康改善更為明顯(P<0.05)。其余指標(biāo)組間相近(P>0.05)。結(jié)論普濟痔瘡栓治療混合痔術(shù)后的安全有效，且可明顯提高患者炎癥和生活質(zhì)量。關(guān)鍵詞：普濟痔瘡栓;混合痔術(shù)后;炎癥;生活質(zhì)量;收稿日期：2017-09-17ClinicalObservationofPujiZhichuangSuppositoryintheTreatmentofMixedHemorrhoi
3、dsafterSurgeryWANGHaixiaTraditionalChineseMedicinePharmacy.theAffiliatedSecondHospitalofShanxiMedicalUniversity;Abstract：ObjectiveToobservetheeffectandsafetyofPujiZhichuangsuppositoryonmixedhemorrhoidaftersurgery,andtheimpactoninflammationandqualityoflife.Methods91casesofpatientswithmixedhemorrho
4、idaftersurgerywererandomlydividedintocontrolgroup(45cases)andobservationgroup(46cases).ThecontrolgroupreceivedcompoundherbalschizonepetaesmokedlotionandGangtaisuppository,andthestudygroupreceivedcompoundherbalschizonepetaesmokedlotionandPujiZhichuangsuppository.Theedemasubsided,painsubsided,bleed
5、ingstopandwoundhealingtime,clinicaleffectandadversereactionwerecompared.SerumlevelofIL-6,IL-8andTNF-awasdeterminedbyELISA.SF-36scalewasusedtoevaluatethequalityoflife.ResultsFortheobservationgroup,theaveragetimeofedemasubsided,painsubsidedandwoundhealingwas(9.10±1.37)d，(6.68±1.14)dand(14.17±3.32)d
6、,respectively,whichwereshorterthan(12.45土3.17)d,(8.04士1.23)dand(18.16土3.02)dofthecontrolgroup.Thetotalclinicaleffectiverateoftheobservationgroupwas87.0%,whichwashigherthan68.9%ofthecontrolgroup.Oneweekafteroperation,theserumlevelofIL-6,IL-8andTNF-cioftheobservationgroupwaslowerthanthoseofcontrolg
7、roup.Thephysiologicalfunction,bodilypain,vitalityandemotionalhealthimprovedgreatly(P<0.05).Theotherindexesofthetwogroupsweresimilar(P>0.05).ConclusionPujiZhichuangsuppositoryiseffectiveandsafeforpatientswithmixedhemorr
