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1、小劑量氨磺必利聯(lián)合鹽酸氟西汀治療首次抑郁發(fā)作的臨床研宄(宜賓市礦山急救醫(yī)院精神科四川宜賓644500)【摘要】目的:首次抑郁發(fā)作小劑量氨磺必利聯(lián)合鹽酸氟西汀的治療效果與安全性評價(jià)分析。方法:選取我院2014-2015年接診的126例首次抑郁發(fā)作患者作為本次研究對象,依據(jù)臨床所采取治療方法不同將納入病例隨機(jī)分為單純采用鹽酸氟西汀治療的對照組與聯(lián)合使用鹽酸氟西汀與氨磺必利治療的觀察組,參照漢密爾頓抑郁量表分別評價(jià)兩組患者治療前與治療后1、2、4、6、8周抑郁程度,藥物不良反應(yīng)評估以副反應(yīng)量表為參考依據(jù),將兩組治療后患者抑郁改善情況及藥物不良反應(yīng)發(fā)生率作為比較。結(jié)果:治療前兩組
2、漢密爾頓抑郁評分差異無統(tǒng)計(jì)學(xué)意義(P>;0.05);治療后兩組漢密爾頓抑郁評分均有不同程度改善,觀察組治療后1、2周木漢密爾頓抑郁評分顯著低于對照組,組間差異懸殊,具備統(tǒng)計(jì)學(xué)意義(P<0.05)o結(jié)論:氨磺必利與鹽酸氟西汀聯(lián)合用藥方案治療首次抑郁發(fā)作效果優(yōu)于鹽酸氟西汀單用治療方案,兩種藥物聯(lián)用對首次抑郁發(fā)作的控制佳,明顯緩解患者抑郁癥狀,臨床療效與安全性肯定。【關(guān)鍵詞】氨磺必利;鹽酸氟西?。灰钟羰装l(fā)【中圖分類號】R749.05【文獻(xiàn)標(biāo)識碼】A【文章編號】1007-8231(2016)26-0030-02【Abstract】ObjectiveFirstdepres
3、siveepisodesmalldosesoftolbutamideshallbejoined,thecurativeeffectoffluoxetinehydrochlorideandsafetyevaluationanalysis.MethodsOurhospitalin2014-2015alone,126casesofpatientswithdepressiveepisodeastheresearchobject,forthefirsttimetakenonthebasisofclinicaltreatmentwillbeincorporatedintodiffer
4、entcaseswererandomlydividedintosimplicityofthecontrolgrouptreatedwithfluoxetinehydrochlorideandcombinationoffluoxetinehydrochlorideandtolbutamideobservationofthetreatmentgroup,withreferencetotheHamiltondepressionratingscaleevaluationrespectivelybeforeandaftertreatmentinbothgroups1,2,4,6,8
5、weeksdepressionseverity,adversedrugreactionsassessmentscaleforreference,thetwogroupsaftertreatmentinpatientswithdepressiontoimprovethesituationandtocomparetheincidenceofadversedrugreactions.ResultsTheHamiltondepressionratingsimilarbetweenthetwogroupsbeforetreatmenthadnostatisticalsignific
6、ance(P>0.05);Hamiltondepressionratingaftertreatmentintwogroupwereimprovedtovaryingdegrees,theobservationgroupaftertreatment1,2,weekendHamiltondepressionratingissignificantlylowerthancontrolgroup,differencebetweengroup,withstatisticalsignificance(P<0.05).ConclusionTolbutamideadvantag
7、esandfluoxetinehydrochloridecombinationschemewilleffectisbetterthanthatoffluoxetinehydrochlorideforthefirsttimeusetreatment,twokindsofdrugcombinationcontrolofthefirstdepressiveepisode,obviouslyalleviatesymptomsofpatientswithdepression,clinicalefficacyandsafety.【Keyw