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1、氧化樟腦注射液對小鼠睡眠功能等影響的實驗研究焦燕，楊曉春，張問，楊世杰，李紅＊（吉林大學白求恩醫(yī)學院藥理學系，吉林長春130021）摘 要:目的:探討氧化樟腦對小鼠睡眠功能和自主活動的影響。方法:①腹腔注射氧化樟腦10min后,腹腔注射閾劑量的戊巴比妥鈉（45mg/kg）,記錄小鼠入睡時間和睡眠持續(xù)時間。②腹腔注射戊巴比妥鈉（65mg/kg）,待小鼠翻正反射消失后,腹腔注射氧化樟腦,記錄小鼠睡眠時間。③小鼠腹腔注射氧化樟腦,10min后放入YLS-1S多功能小鼠自主活動測定儀中,穩(wěn)定2min后記錄5min內(nèi)小鼠自主活動次數(shù)。結果:①氧化樟腦能顯著延長閾劑量戊巴比妥鈉的小鼠的入睡時
2、間并縮短睡眠持續(xù)時間。②氧化樟腦能顯著縮短閾上劑量戊巴比妥鈉小鼠的睡眠時間,與對照組比較，具有明顯的統(tǒng)計學差異(P<0.05或P<0.01)。③氧化樟腦明顯的增加了小鼠自主活動次數(shù)。結論:氧化樟腦能夠延長小鼠入睡時間、縮短睡眠時間并增加小鼠的自主活動次數(shù)，提示具有催醒的作用。關鍵詞:氧化樟腦；戊巴比妥鈉；睡眠；自主活動Effectstudyofoxcamphorinjectiononmice’ssleepfunctionandotherfunctionJIAOYan,YANGXiao-chun,ZHANGWen,YANGShi-jie,LIHong(DeptofPharmacol
3、ogy,NormanBethuneCollegeofMedicine,JinlinUniversity,Changchun130021,China)Abstract:Objective:Itistoinvestigatetheeffectofoxcamphorinjectiononmice’ssleepfunctionandspontaneousactivity.METHODS:①intraperitonealinjectionofcamphoroxidationafter10min,ofintraperitonealinjectionthethresholddoseofpent
4、obarbitalsodium(45mg/kg),recordedthemice’ssleeplatencyandsleepduration.②intraperitonealinjectionofpentobarbitalsodium(65mg/kg),untillossofrightingreflexinmiceaftertheintraperitonealinjectionofoxcamphor,recordedsleeptimeinmice.③Miceinjedtedintraperitoneallyoxcamphor,10minlater,putthemintotheYL
5、S-1Smulti-functionspontaneousactivitytester,andmadethemiceadaptedthenewenvironmentwithin2min,after5min,recordedthenumberofspontaneousactivityinmice.Results:①Theoxcamphorcansignificantlyprolongethemice’ssleeplatencyandshortsleepdurationatthresholddoseofpentobarbitalsodium.②Oxcamphorcansignific
6、antlyshortensleepingtimeabovethethresholddoseofpentobarbitalsodiuminmice,comparedwiththecontrolgroup,withastatisticallysignificantdifference(P<0.05orP<0.01).③Oxcamphorcansignificantlyincreasethenumberofspontaneousactivityinmice.Conclusion:Theoxcamphorhasthisfunctionthatitcanprolongesleeplaten
7、cy，shortensleepdurationandincreasethenumberofspontaneousactivityinmice.Keywords:oxcamphor;pentobarbitalsodium;sleep;spontaneousactivity氧化樟腦可興奮延腦呼吸中樞和血管運動中樞,也可興奮大腦皮層。氧化樟腦還具有興奮心臟的功能,對于衰弱的心臟,可使其心臟收縮加強,恢復心臟的節(jié)律,增加每分鐘的排出量,從而達到盡快恢復全身正常循環(huán)的作用[1]。另外有研究
