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1、KKME---專業(yè)醫(yī)學搜索引擎http://www.kkme.net/重組人腦利鈉肽對老年充血性心力衰竭的療效評價 作者：夏中華，劉 瓊作者單位：桂林醫(yī)學院附屬醫(yī)院心內(nèi)科，廣西桂林 541001 【摘要】目的：研究靜脈注射重組人腦利鈉肽(rhBNP)治療老年充血性心力衰竭患者的療效。方法：118例老年充血性心力衰竭患者被隨機分為：常規(guī)治療組(56例)，給予常規(guī)藥物治療;rhBNP組(n=62)，以rhBNP1.5Μg/kg靜脈注射后，再以0.0075Μg/kg連續(xù)滴注;觀察兩組治療前后超聲心動圖變化，血漿N末端腦利鈉肽前體(NT-proBNP)濃度的變化以及出院后患者主要心血管
2、事件的發(fā)生情況。結(jié)果：與治療前比較，治療5d后rhBNP組左室射血分數(shù)明顯提高[(0.37±0.10)∶(0.44±0.09)，P<0.05];兩組血漿NT-proBNP水平均有明顯下降[常規(guī)治療組(7532.7±1005.6)pg/ml∶(7056.5±998.3)pg/ml，rhBNP組(7565.1±1102.3)pg/ml∶(6206.7±1137.9)pg/ml，P<0.05]，且rhBNP治療組下降更明顯(P<0.05);兩組患者治療前后左心室舒張末期內(nèi)徑(LVEDd)無明顯變化(P>0.05);在8個月的隨訪期內(nèi)rhBNP組心臟不良事件少于常規(guī)治療組(9.7%∶28.
3、6%)。結(jié)論：重組人腦利鈉肽是治療老年充血性心力衰竭的有效藥物。 【關(guān)鍵詞】利鈉肽,腦,心力衰竭,充血性,老年人 Abstract：Objective：Tostudythetherapeuticeffectsofintravenousinjectionofrecombinanthumanbrainnatriureticpeptide(rhBNP)oncongestiveheartfailure(CHF)inagedpatients.Methods：AKKME---專業(yè)醫(yī)學搜索引擎http://www.kkme.net/totalof118agedpatientswithCHFw
4、ererandomlydividedintoroutinetreatmentgroup(n=56，receivedroutinedrugtreatment)andrhBNPgroup(n=62，receivedrhBNPintravenousinjectionwith1.5Μg/kgwithin90sfollowedby0.0075Μg/kg?minivdropfor48h).ChangesofechocardiogramandplasmaconcentrationofNterminal-proBNP(NT-proBNP)beforeandaftertreatmentandinci
5、denceofmainadversecardiovascularevents(MACE)post-dischargewereobservedandanalyzedinthetwogroups.Results：Comparedwithbeforetreatment，fivedaysaftertreatmentleftventricularejectioninfractionsignificantlyincreased[(0.37±0.10)vs.(0.44±0.09)，P<0.05]inrhBNPgroup.PlasmalevelsofNT-proBNPofthetwogroupss
6、ignificantlydecreased[routinetreatmentgroup(7532.7±1005.6)pg/mlvs.(7056.5±998.3)pg/ml，rhBNPgroup(7565.1±1102.3)pg/mlvs.(6206.7±1137.9)pg/ml，P<0.05]，andit′smoresignificantinrhBNPgroup(P<0.05).Leftventricularend-diastolicdimension(LVEDd)ofthetwogroupsshowednosignificantchangesbeforeandaftertreat
7、ment(P>0.05).Duringfollowupperiodofeightmonths，rhBNPgrouphadfewercardiovascularevents(9.7%)thanroutinetreatmentgroup(28.6%).Conclusion：Recombinanthumanbrainnatriureticpeptideisaneffectivedrugfortreatmentofcongestiveheartfailureinagedpat
