資源描述：
《貝伐單抗脂質(zhì)體聯(lián)合離子電滲對(duì)兔眼后段給藥的分析》由會(huì)員上傳分享，免費(fèi)在線(xiàn)閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、-------廣州醫(yī)科大學(xué)碩士學(xué)位論文freebevacizumabconcentrations，ELISAkitwasused．Thedatawereanalyzedbyt-testandanalysisofvariance．Results：1．Theresultsofocularexamination：Alltheexperimentalanimalswerehealthyduringthewholeproceduals．Therearenoobviouscomplicationsintheeyes，su
2、chaseyeinfections，cornealopacity,cataract，retinalhemorrhageeta1．2.Thecomparisonofdrugconcentration:GroupA、BandC,theaqueoushumorconcentrationofbevaeizumabwas(11.08±0.46)μg/mland(27.53±0.37)μg/mland(38.48±0.15)μg/mlintherighteyes，after24h,respectively.Avitreo
3、usconcentrationofbevaeizumabwas(7.29±0.17)μg/mland(19.25±0.15)μg/mland(31.87±0.25)μg/mlintherighteyes，respectively.Iontophoresisgroup,bevacizumabconcentrationintherighteyesofaqueoushumorandvitreouscavitycomparison.Thedrugconcentrationofaqueoushumorwerehighe
4、rthaninthevitreouscavity,thedifferencewasstatisticallysignificant(P<0.01).Betweeniontophoresisgroup,therewerestatisticallysignificantofdrugconcentrationsinthesameareasthroughvarianceanalysisandcomparisonbetweengroups.Bevacizumabsolutioneyedropsgroup(lefteye
5、ingroupA)，theaqueoushumorandvitreouscavitywerenotdetectedindrugconcentration.Bevacizumabliposomessolutioneyedropsgroup(lefteyeingroupB)，drugconcentrationintheaqueoushumorwas（1.30±0.11）μg/mlandthevitreouscavitywasnotdetectedindrugconcentration.Becausethetwog
6、roupsfailedtodetectdrugconcentrationorconcentrationistoolow,arenotincludedforcomparison.Bevacizumabconcentration(receivedintravitrealinjectedbybevacizumab)inaqueoushumorandvitreouscavitywas(19.37±0.21)μ-----------4萬(wàn)方數(shù)據(jù)-----------英文摘要g/mland(179.83±0.11)μg/m
7、linthelefteyes.Comparedwiththedrugconcentrationindifferentcurrentintensityofiontophoresis,thedifferencehadstatisticalsignificance,P<0.01.Conclusion：Bevacizumabliposomescombinediontophoresisadministration,nosignificantsideeffects,isasafemodeofadministration.
8、Currentinarangeof0.5～2.5mA，thegreaterthecurrentintensity,bevacizumabliposomesintheeyeoftheimportquantityislarger.Bevacizumabliposomescombinediontophoresiswiththerapeuticsignificance,fordrugconcentratio
