資源描述：
《原發(fā)性肝癌中brms1蛋白和caⅰ蛋白表達(dá)及其臨床病理意義》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在應(yīng)用文檔-天天文庫(kù)。
1、七年制碩士學(xué)位論文英文摘要ABSTRACTObjeetiveToinvestigatetheeXPressionofBreastCaneerMetastasisSuPPressorl(BRMSI)ProteinandCarbonie內(nèi)止ydrasel(CAI)ProteininPrimaryHePaticCarcinoma(PHC)，andtoeXPloretherelationshiPsofthemselvesandtheeorrelationbetweenthemandtheclinieoPathologicalcharae
2、teristicsofPHC.MethodsThesPeeimensfrom47PatientswithPrimaryHePatieCarcinoma(PHC)and20eorresPondingParaneoPlastichePatictissueswerefixedin10%formalinandroutinelyembeddedinParaffin.Thespeeimenswereeontinuouslyslieedinto4卿一thicksections.EnvisionTMimmunohistoehemistrywas
3、PerformedtodeteettheexPressionsofBRMS1ProteinandCA1Proteinwithmonoelonalantibodiesandscoredthemunderhigh一PowermicroscoPy.ResultsInthe47PrimaryHePatieCareinoma(PHC)eases，therearesignifieantlystatisticaldistinctionsintheexPressivePositiverateandtheeXPressivescoresofBRM
4、S1andCA1ProteinbetweencaneertissuesandParaneoPlastietissues(P<0.01，P<0.05).TheeaneertissueswithintrahePatiemetastasisandtumorthrombosishavesignifieantlylowerexPressivePositiverateandexPressiveseoresofBRMS1proteinthantheothers(p<0.01，p<0.05)，andalsothereisasinifieantl
5、ylowerPositiverateinnodularanddiffusePHCthanmassive七年制碩士學(xué)位論文英文摘要ones(P<0.05).Butwehaven’tfoundtherelatioshiPsbetweenB側(cè)MSIandothermainelinieoPathologiealeharaeteristicsofPHC(P>0.05).There15nocorrelationbetweentheexPressionofCA1ProteinandclinieoPathologiealeharaeterist
6、iesofPHC，exeePtthattheeXPressivePositiverateandtheeXPressivescoresofPHCsignificanilygraduallyinereasewiththedescendingdifferentiationdegree(P<0.05).There15noevidentcorrelationbetweentheexPressiveseoresofBR五江51ProteinandthatofCA1ProteinineaneertissuesofPHC(r=-0.37，尸>0
7、.05).ConclusionThelostexPressionofBRMS1ProteininPHCPlaysanimPotantroleintheinvasiveandmetastatieProeess，withouteffeetonthetransformationandgrowthofPHC.Ontheeontrary，theovereXPressionofCA1ProteininPHC15eloselyrelatedtothedifferentiation，anditmayhavenothingtodowiththeg
8、ro叭h、invasivenessandmetastasis.Andthere15noeorrelationbetweentheeXPressiveseoresofBRMS1ProteinandthatofCA1ProteinineaneertissuesofP
