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《美國(guó)修訂精苯霜靈（Benalaxyl-M）殘留限量要求（Benalaxyl-M；Pesticide Tolerances）.doc》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、美國(guó)修訂精苯霜靈（Benalaxyl-M）殘留限量要求（Benalaxyl-M；PesticideTolerances）1.Dietaryexposurefromfoodandfeeduses.Inevaluatingdietaryexposuretobenalaxyl-M,EPAassesseddietaryexposuresfrombenalaxyl-Minfoodasfollows:i.Acuteexposure.Nosucheffectswereidentifiedinthetoxicologicalstudiesforbenalaxyl-M;therefore,aquanti
2、tativeacutedietaryexposureassessmentisunnecessary.ii.Chronicexposure.InconductingthechronicdietaryexposureassessmentEPAusedthefoodconsumptiondatafromtheUSDAxx-xxCSFII.Astoresiduelevelsinfood,EPAusedtolerance-levelresiduesand100%croptreated.iii.Cancer.EPAdetermineswhetherquantitativecancerexposur
3、eandriskassessmentsareappropriateforafood-usepesticidebasedontheweightoftheevidencefromcancerstudiesandotherrelevantdata.Ifquantitativecancerriskassessmentisappropriate,cancerriskmaybequantifiedusingalinearornonlinearapproach.Ifsufficientinformationonthecarcinogenicmodeofactionisavailable,athres
4、holdornonlinearapproachisusedandacancerRfDiscalculatedbasedonanearliernoncancerkeyevent.Ifcarcinogenicmodeofactiondataarenotavailable,orifthemodeofactiondatadeterminesamutagenicmodeofaction,adefaultlinearcancerslopefactorapproachisutilized.BasedonthedatasummarizedinUnit,EPAhasconcludedthatbenala
5、xyl-Mshouldbeclassifiedas“LikelytobeCarcinogenictoHumans”andalinearapproachhasbeenusedtoquantifycancerrisk.CancerriskwasquantifiedusingthesameestimatesasdiscussedinUnit,chronicexposure.iv.Anticipatedresidueandpercentcroptreated(PCT)information.EPAdidnotuseanticipatedresidueand/orPCTinformationin
6、thedietaryassessmentforbenalaxyl-M.Tolerancelevelresiduesand/or100%CTwereassumedforallfoodcommodities.2.Dietaryexposurefromdrinkingwater.Anassessmentofresiduesindrinkingwaterisnotrequiredforthisassessmentbecausethereisnodrinkingwaterexposureintheassociatedwiththeestablishmentofanimporttolerance.
7、3.Fromnon-dietaryexposure.Theterm“residentialexposure”isusedinthisdocumenttorefertonon-occupational,non-dietaryexposure(,forlawnandgardenpestcontrol,indoorpestcontrol,termiticides,andfleaandtickcontrolonpets).Benalaxyl-Misno
