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1、分類號學(xué)號M200975911學(xué)校代碼10487密級碩士學(xué)位論文HPLC-MS/MS法測定人血漿中頭孢克洛和頭孢克肟的濃度及其人體生物等效性研究學(xué)位申請人：李冬艷學(xué)科專業(yè)：藥劑學(xué)指導(dǎo)教師：丁水平副教授答辯日期：2012年5月AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofMasterofMedicineDeterminationofcefaclorandcefiximeinhumanplasmabyhighperformanceliq
2、uidchromatorgraphywithtandemmassspectrometryandstudyonbioequivalenceCandidate:LiDongyanMajor:PharmacySupervisor:AssociateProfessorDingShuipingTongjiHospital,TongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan,Hubei430030,P.R.ChinaMay,2012獨創(chuàng)性聲明本人鄭重聲明，本學(xué)位論文是本人在
3、導(dǎo)師指導(dǎo)下進行的研究工作及取得的研究成果的總結(jié)。盡我所知，除文中已經(jīng)標明引用的內(nèi)容外，本論文不包含任何其他個人或集體已經(jīng)發(fā)表或撰寫過的研究成果。對本文的研究做出貢獻的個人和集體，均已在文中以明確方式標明。本人完全意識到本人將承擔(dān)本聲明引起的一切法律后果。學(xué)位論文作者簽名：日期：年月日學(xué)位論文版權(quán)使用授權(quán)書本學(xué)位論文作者完全了解學(xué)校有關(guān)保留、使用學(xué)位論文的規(guī)定，即：學(xué)校有權(quán)保留并向國家有關(guān)部門或機構(gòu)送交論文的復(fù)印件和電子版，允許論文被查閱和借閱。本人授權(quán)華中科技大學(xué)可以將本學(xué)位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫進行檢索，可以采用影印、縮印或掃
4、描等復(fù)制手段保存和匯編本學(xué)位論文。保密□，在_____年解密后適用本授權(quán)書。本論文屬于不保密□。（請在以上方框內(nèi)打“√”）學(xué)位論文作者簽名：指導(dǎo)教師簽名：日期：年月日日期：年月日目錄摘要··············································································································1Abstract·····························································
5、··········································3前言··············································································································6第一部分HPLC-MS/MS測定人血漿中頭孢克洛的濃度及頭孢克洛干混懸劑的生物等效性究········································································81
6、.試驗?zāi)康摹ぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁ?2.試驗設(shè)計························································································93.分析測試方法············································································
7、···134.實驗結(jié)果························································································285.結(jié)論與討論····················································································40第二部分HPLC-MS/MS測定人血漿中頭孢克肟的濃度及頭孢克肟干混懸劑的生物等效性研究···································
8、·································421.試驗?zāi)康摹ぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁ?/p>
