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《xrcc4在乳腺癌組織中的表達(dá)與其臨床意義》由會員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、XRCC4在乳腺癌組織中的表達(dá)及其臨床意義ABSTRACTBackgroundBreastcanceristhemostprevalentcancerinwomenaroundtheworld，becomingthefastestgrowingcancerinurbanmortality．DNAdoublestrandbreaks(DSBs)，whichhappenatrelativeorneighboringbasesinbotllstrand,isthecrucialpointamongthosepath
2、ogenesisofbreastcancer．Asoneofthemostsevereinjuriesofcells，DSBscallcausedeletionandrearrangementofgeneticinformationandsubsequentlyresultinapoptosisormutation．DSBsrepairinvolvestwosignalingpathway：non-homologousendjoining(NHEJ)andhomologousrecombinational(I
3、-IR)．NHEJ，whichisthemainlyrepairmodeineukaryotes，mcanswi也thehelpofrepairablecomponent,DNAattheendsofthefractureseormectdirectlyindependentoftheDNAhomology．What'smore，X—myrepaircrosscomplementingprotein4(XRCC4)playinganimportantroleinNHEJpathway,isthevitalho
4、usekeepinggeneaboutmaintainingthestabilityofgenome．Previousstudieshaveconfirmedthat—singlenucleotidepolymorphism(SHIP)inXRCC4isrelevanttotheriskofbreastcancer,however,lessresearcheshavebeendoneaboutproteinexpressioninbreastcancertissues．objectiveDepended011
5、variousclinicaldatacollectionandtissuemicroarray,throughstudyingonXRCC4expressioninrespectivelybreastCanCertissuesandadjacentnormaltissues，andsubsequentlycombinetheresultswithclinicopathologicalparametersandoverallsurvival(OS)，thisresearchisaimedatinvestiga
6、tingwhetherXRCC4Callbetreatedasbreastpredictorandprognosticfactor,andfurtheranalysisingtheexpressionofXRCC4indifferentsubtypesofbreastcancer,andguidingclinicaltherapy．MethodsCollect284surgicalspecimensfrombreastcancerpatientsand77specimensaboutadjacentnorma
7、ltissueinthem；thencollect132surgicalspecimensfromtriplenegativebreastcancerpatientsand90specimensaboutadjacentnormaltissueinthem,aftermakingthemintotissuemicroarray,wecallinvestigatetheexpressionandclinicalsignificanceofXRCC4inrespectivelybreastcancertissue
8、s，triplenegativebreastcancertissuesandadjacentnormaltissuesbyusingimmunohistoehemicalmethod(Envisionmethod)．SPSS19．0so做vareapplicationsofthedatawillbeused．3．第二軍醫(yī)大學(xué)碩士學(xué)位論文．4一forstatistical．a(chǎn)nalysis．P<0．0
