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1、左卡尼丁對維持性血液透析患者微炎癥狀態(tài)的影響向遠湘李勇飛汪洋暢(廣東省清遠市清新區(qū)人民醫(yī)院腎內(nèi)科廣東清遠511800)【摘要】目的探討左卡尼丁對維持性血液透析(MHD)患者微炎癥狀態(tài)的影響。方法選擇透析齡超過6個月的MHD患者80例，隨機分為治療組和對照組。每次透析結(jié)束后，治療組給予靜脈注射左卡尼丁1克，療程為3個月。治療前和療程結(jié)束后，分別測量患者血漿C反應蛋白(CRP)、白細胞介素1(IL-1)>白細胞介素6(IL?6)、腫瘤壞死因子(TNF-α)的含量。結(jié)果治療組療程完成后CRP、IL-1>IL?6、TNF-α均
2、較治療前顯著下降(P<0.05)；對照組IL?1療程完成后較治療前明顯下降(P<0.05),CRP、IL?6、TNF-α療程完成后雖較治療前有所下降，但差異無顯著性(P>0.05)；治療后組間比較，CRP、IL?6、TNF-α差異有統(tǒng)計學意義，而IL-1治療組雖較對照組下降，但差異無顯著性(P>0.05)o結(jié)論左卡尼丁可明顯改善患者的微炎癥狀態(tài)，提高透析患者的生活質(zhì)量?！娟P(guān)鍵詞】左卡尼丁血液透析微炎癥狀態(tài)【中圖分類號】R459.6【文獻標識碼】A【文章編號】2095-1752(2013)14-0160-02Effect
3、sofL-carnifineonMicro-inflammnationConditionofMainfenanceHemodialysisXIANGYuanxiang,LIYongfei,WANGYangchang.DepartmentofNephrology,people'sHospitalofQingxinDistrictQingyuanCityinGuangdongProvince,Qingyuan511800,China【Abstract】ObjectiveDiscussingtheeffectofL-carnitin
4、eonmicro-inflammationconditionofmaintenancehemodialysis(MHD)patients.Method80MHDpatientswhohadHDformorethan6monthswereinvolved.Patientsweredividedintothetreatmentgroupandthecontrolgrouprandomly.ThetreatmentgroupweregivenintravenousinjectionofL-carnitinelgafterHDfor3monthes.
5、ThecontentofCRP,IL-1JL-6andTNF-αofpatientsweretestedbeforeandafterthetreatmentcourseseparately.ResultThecontentofCRP,IL-1JL-6andTNF-αofthetreatmentgroupdecreasedapparentlyafterthetreatmentcourse(P<0.05);thecontentofIL-1ofthecontrolgroupdecreasedapparentlycomp
6、aringtopriortreatment(P<0.05);CRP,IL-6andTNF-αreducedafterthetreatment,buttherewerenosign訐icantdifferencesbetweentpriorandafterthetreatment(P>O.O5).TherewerestatisticaldifferencesofCRRIL-6andTNF-αbetweenthetwogroupsafterthetreatment;whiletherewerenosign訐ic
7、antdifferencesofIL-1(P>O.O5)betweenthetwogroupalthoughtheparameterofthetreatmentgroupdecreased.ConclusionL-carnitinecouldimprovethemicro-inflammationconditionofthepatientapparently,andimprovethepatients’qualityoflife?【Keywords]L-carnitinehemodialysismicro-inflammat
8、ioncondition尿毒癥患者普遍存在著以炎癥細胞因子輕度升高為特征的微炎癥狀態(tài)[l]o而微炎癥狀態(tài)和尿毒癥并發(fā)癥有關(guān)。因此，微炎癥狀態(tài)的防治是降低尿毒癥并發(fā)癥
