資源描述:
《鼻咽癌三種布野方案對(duì)調(diào)強(qiáng)放療劑量分布的影響》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在教育資源-天天文庫(kù)。
1、萬(wàn)方數(shù)據(jù)鼻咽癌三種布野方案對(duì)調(diào)強(qiáng)放療劑量分布的影響伍志紅張九堂’曾彪魯旭蔚(湖南省腫瘤醫(yī)院放療綜合科,湖南長(zhǎng)沙410013)[摘要]【目的】比較鼻咽癌調(diào)強(qiáng)放療三種布野方案之間的差異,為鼻咽癌調(diào)強(qiáng)計(jì)劃選擇布野方案提供參考。【方法】對(duì)lo例鼻咽癌病例選用A、B、C三種布野方案,應(yīng)用相同的物理目標(biāo)函數(shù)和約束條件,利用直接子野優(yōu)化進(jìn)行鼻咽癌調(diào)強(qiáng)放療計(jì)劃的設(shè)計(jì)。用劑量體積直方圖(DVH),靶區(qū)適形度指數(shù)(cI),危及器官劑量分布,機(jī)器跳數(shù),子野數(shù)目以及治療過(guò)程中是否需要2次擺位作為計(jì)劃評(píng)價(jià)指標(biāo)進(jìn)行比較。【結(jié)果】A,B,C三種方案中,
2、脊髓,腦干,垂體.晶體,口腔的體積量沒有明顯的區(qū)別,A,B兩種7野方案,靶區(qū)覆蓋度(1395,V100),靶區(qū)均勻性(Dl一/鞏。)。適形度指數(shù)(CI),均無(wú)顯著性差異(P>O.05)。但是A方案治療過(guò)程中需要2次擺位。9野方案即C方案的靶區(qū)覆蓋度,靶區(qū)均勻性比A,B方案稍好,但包括靶區(qū)適形度無(wú)顯著性差異(P>o.05),但機(jī)器跳數(shù)和子野教目均比A,B方案低5%,治療過(guò)程中也需要2次擺位?!窘Y(jié)論】利用直接子野優(yōu)化進(jìn)行鼻咽癌調(diào)強(qiáng)放療計(jì)劃的設(shè)計(jì),7野方案就足以滿足臨床的要求,考慮到治療過(guò)程中擺位的重復(fù)性以及放射生物效應(yīng),B方案
3、是最優(yōu)選擇。[關(guān)鍵詞]鼻咽腫瘤/放射療法ComparisonamongThreeKindsofFieldArrangementofIntensityModulatedRadiotherapyforNasopharyngealCarcinomaWUZ^i—hong,ZHANGJiu—tang。ZENGBiao。dal(DepartmentofRadiotherapy,HunanTumorHospital,Otangsha410013,GIlina>[Abstract][Objective]Tostudythedif.fere
4、neesofthreekindsoffieldarrangementofintensitymodulatedradiationtherapy(1MRT)fornasopharyngealcarcinoma(NPC)andtofindtheoptimalfieldarrangement.[Methods]ThefieldarrangementA,BandCwereusedfor10easesofNPC.Theplanofintensitymodulatedradiotherapywasdesignedwiththesamep
5、hysicalgoalfunctionandconstrainedconditionanddirectsegmentoptimizatiofi.Thedosevolumehistogram(DVH),conformityindex(CI)oftargetregion,maxdoseoftheor-gan,thenumberofsegment,MU,andwhetherneededtwiceset-upineachtreatmentwerecompared.[Re-suits]IntheplanA,BandC,thewlax
6、doseofspinalcord,thebrainstem,hypophysis.1ensanddosevolumeoforalcavityhadnoobviousdifferences.IntheplanAwith7fields,thetargetdosecoverage(D95,V100).thetargetdoseuniformity(Dm/D‰),theconfofruityindex(CI)weresimilartotheplanBwhichwasalsowith7fields.ButtheplanAneeded
7、set-uptwice.Inthedesignof9fieldsplan,thetargetdosecoverage,thetargetdoseunifortuity,theconformityindex(CI)wasalitterbetterthanthoseinplanAandB.TheC1oftheplanCwassimilartothatofplanAandplanB.ThenumberofsegmentandMUweredecreased5%,SOitneededtwiceset-upalso.[Conclusi
8、on]WithUtilizingtheDSStooptimizetheIMRTplanofNPC,7fieldsisenoughtomeetclinicalrequirement.Thinkingoftherepeatofthepositionduringtreatment;theplanBisanop