資源描述:
《通脈飲對(duì)動(dòng)脈粥樣硬化臨床前期病變(pca)干預(yù)的研究》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、提要目的:觀察通脈飲治療動(dòng)脈粥樣硬化臨床前期(PCA)病變的臨床療效。方法:將60例動(dòng)脈粥樣硬化臨床前期病變患者隨機(jī)分為兩組,藥物組30例,給予通脈飲治療;對(duì)照組30例,給予強(qiáng)化生活方式指導(dǎo),隨訪1年時(shí)間。結(jié)果:藥物組成員的總膽固醇(TC)和低密度脂蛋白(LDL-C)有顯著降低(P<0.01);對(duì)照組TC和LDL-C有顯著降低(P<0.01),兩組的甘油三脂(TG)和高密度脂蛋白(HDL-C)在治療前后沒(méi)有達(dá)到統(tǒng)計(jì)學(xué)差異,藥物組的TC較對(duì)照組降低(P=0.042,P<0.05),LDL-C也顯著降低(P=0.004,P<0.01),而TG和HDL-C在兩組間沒(méi)有達(dá)到統(tǒng)計(jì)學(xué)差
2、異。藥物組和對(duì)照組的頸動(dòng)脈內(nèi)-中膜厚度(IMT)和頸動(dòng)脈粥樣硬化斑塊Crouse積分在治療后均有顯著改善(P<0.01),而在藥物組和對(duì)照組間,則未達(dá)到統(tǒng)計(jì)學(xué)差異(P=0.733,P=0.688)。藥物組肱動(dòng)脈-踝動(dòng)脈脈搏波速度(baPWV)顯著降低(P<0.01),對(duì)照組則沒(méi)有降低(P=0.156);藥物組baPWV低于對(duì)照組(P=0.037,P<0.05)。結(jié)論:通脈飲可以顯著改善PCA患者的動(dòng)脈結(jié)構(gòu)和功能,強(qiáng)化生活方式也能一定程度的改善動(dòng)脈結(jié)構(gòu)和功能,但效果弱于通脈飲。以祛痰化瘀法組方的通脈飲,治療動(dòng)脈粥樣硬化臨床前期病變具有顯著的療效。關(guān)鍵詞通脈飲;動(dòng)脈粥樣硬化臨床
3、前期病變;強(qiáng)化生活方式;臨床研究TheClinicalStudyonPreclinicalAtherosclerosis(PCA)TreatedwithTheTONG-MAI-YINSpeciality:InternalmedicineofTCMAuthor:ZhaoYanxiangTutor:WangYingAbstractObjective:ToobservetheclinicaleffectoftheprescriptionofTONG-MAI-YINonPreclinicalAtherosclerosis(PCA).Methods:60patientsofPrecl
4、inicalAtherosclerosiswererandomlydividedintotreatmentgroup(30cases)andcontrolgroup(30cases).TONG-MAI-YINGcapsulewasgiventotreatmentgroup.Strengthenwayoflifewasgiventocontrolgroup.theinfluencesofclinicaleffectonPCAwereobservedduring1year.Results:Inthetreatmentgroupandthecontrolgroup,theTota
5、lCholesterol(TC)andLDL-ChavebeendramaticallyReduced(P<0.01).triglyceride(TG)andHDL-Chavenotreachedstatisticaldifferencesaftertheyweretreated.TCofthetreatmentgrouphasbeenlowerthanthecontrolgroup(P=0.042,P<0.05)andalsotheLDL-C(P=0.004,P<0.01).TGandHDL-Chavenotreachedstatisticaldifferencesbet
6、weenthetwogroups.IMTandCrouseintegralhaveimprovedsignificantlyafterbeentreatedinbothgroups(P<0.01).Buttheyhavenotreacheddifferencesbetweenthetwogroups(P=0.733,P=0.688).thebaPWVofthetreatmentgrouphasDramaticallyReduced(P<0.01),butnotinthecontrolgroup(P=0.156);baPWVofthethetreatmentgrouphasb
7、eenlowerthanwhatisinthecontrolgroup(P=0.037,P<0.05).Conclusion:TONG-MAI-YINcanimprovetheartery'sstructureandfunctionofthepatientswithPCA.Strengthenwayoflifecanalsoimprovetheartery'sstructureandfunctiontosomeextent,butitseffecthasbeenweakerthantheTONG-MAI-YIN.K