順鉑對lewis肺癌小鼠體內(nèi)mdsc的影響及其可能機(jī)制的探討

順鉑對lewis肺癌小鼠體內(nèi)mdsc的影響及其可能機(jī)制的探討

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時間:2019-03-10

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1、萬方數(shù)據(jù)復(fù)旦大學(xué)碩士學(xué)位淪文復(fù)旦大學(xué)碩士學(xué)位論文順鉑對Lewis肺癌小鼠體內(nèi)佃SC的影響及其可能機(jī)制的探討Thestudyontheea℃ctandpossiblemechanismofcisplatinonMDSCsinT●1●‘LeWlSlungCanCerbearingmiCe院系:復(fù)旦大學(xué)附屬華山醫(yī)院專業(yè):腫瘤學(xué)姓名:王甜指導(dǎo)老師:梁曉華主任醫(yī)師導(dǎo)師小組:周鑫莉副主任醫(yī)師黃若凡主治醫(yī)師完成日期:2013年4月2日萬方數(shù)據(jù)目錄中英文縮略詞表·····································中文摘要··················

2、··-·-····················英文摘要···········································引言···············································材料和方法·········································1.材料·····························-···一·一··1.1實(shí)驗(yàn)動物·······························1.2細(xì)胞來源······························

3、·1.3主要試劑···························-·1.4所需溶劑配制方法·······················1.5主要耗材和儀器··················-·-····2.實(shí)驗(yàn)方法與步驟·····························2.1細(xì)胞培養(yǎng)······························2.2Lewis肺癌模型鼠建立及給藥············2.3標(biāo)本采集········-····················2.4操作步驟····························結(jié)果

4、·········-····································1順鉑對小鼠體內(nèi)如Sc的數(shù)量的影響··-·······1.1順鉑對硒sC在腫瘤組織中數(shù)量的影響····1.2順鉑對如SC在荷瘤小鼠脾臟中數(shù)量的影響··2.順鉑對小鼠體內(nèi)Galectin_3的影響··········l258地挖攏抱他屹媳M坫垢加毖船萬方數(shù)據(jù)2.1.Galectin一3在荷瘤小鼠組織中表達(dá)量的變化···232.2.Galectin一3在荷瘤小鼠外周血中表達(dá)量的變化··253.Galectin一3在Lewis肺癌細(xì)胞中的表達(dá)·········264.Galec

5、tin一3在如SC中的表達(dá)····················285.Galectin一3對肋SC的趨化作用·--············296.Galectin一3對如SC的凋亡的影響··············317.Galectin一3促進(jìn)骨髓前體細(xì)胞分化為如SC·······32討論····················-·--·-··-···················34結(jié)論·········································-······38創(chuàng)新點(diǎn)·······························

6、··············39參考文獻(xiàn)···········································40綜述····························-··-·-·············47致謝···············································58聲明············-··································59萬方數(shù)據(jù)復(fù)旦大學(xué)碩士學(xué)位論文中英文縮略詞表Abbreviation萬方數(shù)據(jù)復(fù)旦大學(xué)碩士學(xué)位論文順鉑對Lewis肺癌小鼠體內(nèi)如SC的影

7、響及其可能機(jī)制的探討中文摘要【目的】化療藥物在損傷腫瘤細(xì)胞的同時也干擾機(jī)體的免疫系統(tǒng)?;熀蠛闪鰴C(jī)體內(nèi)的免疫格局形成對腫瘤的復(fù)發(fā)、進(jìn)展等有重要意義。髓系來源抑制性細(xì)胞(MyeliodDerived—suppressorCells,MDSCs)是誘導(dǎo)機(jī)體產(chǎn)生免疫抑制的重要細(xì)胞,并成為腫瘤誘導(dǎo)的免疫耐受的研究熱點(diǎn)之一。MDSC作為一群未成熟的免疫抑制性細(xì)胞在包括肺癌在內(nèi)的多種腫瘤機(jī)體中異常聚集,這與體內(nèi)的諸多調(diào)節(jié)性因子發(fā)生變化有關(guān)?;罴?xì)胞損傷釋放出具有免疫調(diào)節(jié)活性的損傷相關(guān)分子模式(DamageAssociatedMolecularpatterns,DAMPs),半

8、乳糖凝集素3(Galec

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