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1、上海交通大學(xué)碩士學(xué)位論文FHIT在乳腺癌中的表達(dá)及其與臨床病理指標(biāo)之間的關(guān)系姓名:徐國萍申請學(xué)位級別:碩士專業(yè):外科學(xué)(普外科)指導(dǎo)教師:何萍青20080501結(jié)論:FHIT表達(dá)降低可能對乳腺癌的演化和進(jìn)展具有一定重要作用;與浸潤性導(dǎo)管癌的淋巴結(jié)轉(zhuǎn)移、臨床分期密切相關(guān);與Cerb-B2、p53表達(dá)相關(guān),可為乳腺癌的早期診斷、進(jìn)一步治療及預(yù)后判斷提供必要的理論依據(jù)。關(guān)鍵詞乳腺癌,F(xiàn)HIT,Cerb-B2,p53,免疫組化EXPRESSIONCHARACTERISTICSOFFHITINBREASTCARCINOMASANDITSRELATIONSHIPWITHCLI
2、NICOPATHOLOGIALPARAMETERSABSTRACTObjective:TostudytheexpressionofFHITinbenignandmalignantbreastdiseaseanditsrelationshipwithclinicopathologicalparametersinbreastcarcinoma.Toapproachitsclinicalsignificanceofguidingthetreatmentandprognosisdirectionsofbreastcarcinoma.Methods:Theexpressio
3、nofFHITwasdetectedbyimmunohistochemistryin42infitratingductalcarcinomatissues,8intraductalcarcinomatissues,16atypicalhyperplasiaofductalepitheliumtissuesand30mastopathiatissues,andrunthepathologicobservationandsemiquantitativeanalysisofFHIT.Results:ThepositiveexpressionofFHITinmastopa
4、thiatissues,atypicalhyper-plasiaofductalepitheliumtissues,intraductalcarcinomatissues,infitratingductalcarcinomatissuesdeclinedbydegrees.Thereisstatisticaldifferencebetweenthem(P<0.01).ThenegativeexpressionrateofFHITinbreastcarcinomatissueswithlymphnodemetastaseswassignificantlyhigher
5、thanthatwithnolymphnodemetastases(P<0.05).ThepositiveexpressionrateofFHITwasfoundin90.0%(stageI)、43.7%(stageII)、12.5%(stageIII).Thereisstatisticaldifferencebetweenthem(P<0.01).ThepresenceofFHITandCerb-B2arenegativecorrelationstatisticallyandrS=-0.357(P<0.05).ThepresenceofFHITandP53are
6、positivecorrelationstatisticallyandrS=-0.360(P<0.05).NostatisticallysignificantdifferencebetweenFHITandage,tumorsize,histologicalclass,ER,PRwasnotedininvasivecarcinoma(P>0.05).Conclusions:TheseresultssuggestthatthereducedexpressionofFHITmayplayanimportantroleindevelopmentandprogressio
7、nofbreastcarcinoma.TheremaybeanassociationbetweenexpressionofFHITandlymphnodemetastases,TNMstage,highexpressionofCerb-B2andp53alteration.Itmayofferguidetoearlydiagnosis,furthertreatmentandprognosisdirections.KEYWORDS:breastcancer,FHIT,cerb-B2,p53,immunohistochemistry上海交通大學(xué)學(xué)位論文原創(chuàng)性聲明本人鄭
8、重聲明:所