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5、2.Press,2000:401-458.[15]JILY,XUZL.Acomparativestudyofclozapinecombined收稿日期：2011-12-16替米沙坦對原發(fā)性高血壓患者動脈彈性的影響*黃漢輝，鄭師明，梅崢嶸，嚴鵬科(廣州醫(yī)學(xué)院第三附屬醫(yī)院藥學(xué)部，廣州510150)摘要：目的研究替米沙坦對原發(fā)性高血壓患者動脈彈性的影響，探討替米沙坦對動脈血管彈性病理性降低的逆轉(zhuǎn)機制。?1方法入選原發(fā)性高血壓患者127例，應(yīng)用替米沙坦80mg·d治療3個月，測定患者治療前后血清一氧化氮、血清瘦素水平及
6、觀察大、小動脈彈性指數(shù)。結(jié)果替米沙坦治療3個月，原發(fā)性高血壓患者總體血壓水平下降(P<0.05)，達到降壓治療的目的。替米沙坦極顯著性降低血清瘦素水平(P<0.01)，顯著提高血清一氧化氮濃度(P<0.05)，并提升大動脈彈性指數(shù)和小動脈彈性指數(shù)(P<0.01)。結(jié)論替米沙坦能控制原發(fā)性高血壓并改善動脈彈性。關(guān)鍵詞：替米沙坦；原發(fā)性高血壓；動脈彈性；一氧化氮；瘦素中圖分類號：R969.4文獻標志碼：B文章編號：1007-7693(2012)06-0554-04EffectofTelmisartanTreatme
7、ntonArteryElasticityinEssentialHypertension*HUANGHanhui,ZHENGShiming,MEIZhengrong,YANPengke(DepartmentofPharmacy,theThirdAffiliatedHospitalofGuangzhouMedicalUniversity,Guangzhou510150,China)ABSTRACT:OBJECTIVETodiscusstheeffectoftelmisartantreatmentonarteryel
8、asticityinessentialhypertension(EH)andtoinvestigatethemechanismoftelmisartanthatreversethepathologicalchangesofarteryelasticity.METHODSTotally?1127patientswithessentialhypertensionwerechosentobe
