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1、—464—中華消化雜志2004年8月第24卷第8期ChinJDig,August2004,Vol.24,No.8·論著·加貝酯對(duì)Oddi括約肌運(yùn)動(dòng)的影響吳叔明徐華戈之錚莫?jiǎng)χ谊悇倭紬畲ㄈA【摘要】目的觀(guān)察加貝酯對(duì)Oddi括約肌運(yùn)動(dòng)功能的影響。方法對(duì)我院12例行內(nèi)鏡下逆行胰膽管造影(ERCP)患者于內(nèi)鏡下作Oddi括約肌測(cè)壓術(shù),記錄Oddi括約肌的基礎(chǔ)壓、基礎(chǔ)收縮幅度、收縮-1-1頻率和運(yùn)動(dòng)指數(shù)(基礎(chǔ)收縮幅度×收縮頻率),并在靜脈滴注加貝酯1、3mg·kg·h前后,分別重復(fù)以上測(cè)壓過(guò)程。以用藥前后記錄數(shù)
2、據(jù)作自身對(duì)照配對(duì)t檢驗(yàn)進(jìn)行統(tǒng)計(jì)學(xué)處理。結(jié)果①靜脈滴注加貝酯-1-11、3mg·kg·h不影響Oddi括約肌的基礎(chǔ)壓(P>0.05)和基礎(chǔ)收縮幅度(P>0.05)。②加貝酯能明-1-1顯減少Oddi括約肌的收縮頻率(P<0.05),但用藥劑量1、3mg·kg·h之間差異無(wú)顯著性(P>0.-1-1-105)。③大劑量加貝酯可明顯降低Oddi括約肌運(yùn)動(dòng)指數(shù)(P<0.01),且3mg·kg·h與1mg·kg·-1-1h劑量間差異也有顯著性(P<0.05)。結(jié)論加貝酯能減少人Oddi括約肌的收縮頻率,3mg·
3、kg·-1h時(shí)還能降低運(yùn)動(dòng)指數(shù)。加貝酯對(duì)Oddi括約肌運(yùn)動(dòng)的影響可解釋加貝酯減少ERCP后胰腺炎的發(fā)生?！娟P(guān)鍵詞】加貝酯;Oddi括約肌;壓力測(cè)定;逆行胰膽管造影EffectsofproteaseinhibitorgabexatemesilateonmotilityofhumanOddi’ssphincterWUShu2ming,XUHua,GEZhi2zheng,etal.DepartmentofGastroenterology,RenjiHospital,ShanghaiSecondMedica
4、lUniversity,Shanghai200001,China【Abstract】ObjectiveToinvestigateeffectsofgabexatemesilateonthemotilityofhumanOddi’ssphincterbyendoscopicmanometry.MethodsTwelvecasesofendoscopicretrogradecholangiopan2-1-1cretography(ERCP)wereinvestigated.Beforeandafteri
5、nfusionofgabexatemesilate1and3mg·kg·h,endoscopicmanometryofOddi’ssphincterwasperformed.Theparametersofbasalpressure,amplitude,fre2quencyofphasiccontractionandmotilityindex(amplitudeperfrequency)weremeasured.Paireddataob2-1-1tainedwasstatisticallyanalyz
6、ed.Results①Gabexatemesilate1and3mg·kg·hneitheraffectedthebasalpressure(P>0.05)northeamplitudeofphasiccontraction(P>0.05).②Gabexatemesilatesignifi2cantlyreducedthefrequencyofcontraction(P<0.05),butnostatisticdifferenceinfrequencyofcontractionwasobserved
7、indifferentdosagegroups(P>0.05).③Highdosegabexatemesilatecouldmarkedlyreducethemotilityindex(P<0.01),therewassignificantdifferencebetweeninfusionofgabexatemesilate1and-1-13mg·kg·h(P<0.05).ConclusionsGabexatemesilatecouldreducethefrequencyofphasiccontra
8、c2-1-1tioninhumanOddisphincter,infusionofgabexatemesilate3mg·kg·hdecreasedmotilityindexaswell.Theresultsuggeststhatgabexatemesilatemaypossiblypreventpost2ERCPpancreatitisduetoitsinhibitingef2fectonmotilityofOddisphincter.【Keywords】Gabex
