足月小于胎齡兒臍血中HO-1的測定與其在臍血管上的表達(dá)

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1、中文摘要與臍血HbCO百分含量均呈正相關(guān)(P<0．05或P0．05)。結(jié)論：1sGA臍血H0一】活性顯著低于AGA，無論AGA還是sGA臍血

2、HO—l活性水平與出生體重均呈正相關(guān)，說明臍血HO—l活性與胎兒富內(nèi)發(fā)育及新生兒營養(yǎng)狀況密切相關(guān)。2SGA臍血血漿HbcO的百分含量均顯著低于AGA，臍向．HO一1活性水平與血漿HbC0百分含量無論AGA還是sGA均呈正相關(guān)。3H0．1在臍【l=

3、1．管上的表達(dá)SGA明顯強(qiáng)于AGA，是由于胎兒宮內(nèi)缺血缺氧，誘導(dǎo)HO一1基因表達(dá)，導(dǎo)致HO一1表達(dá)明顯增高。但其酶的活性受損，加重胎盤胎兒缺m缺氧，影響胎兒生長發(fā)育。因此推測H0．cO系統(tǒng)不僅與妊娠高血壓綜合征所致小于胎齡兒的發(fā)病有關(guān)，而且與其他原因所致非勻稱型小于胎齡兒的發(fā)病均關(guān)系

4、密切。關(guān)鍵詞：血紅素氧合酶(HO一1)；小于胎齡兒(sGA)；臍血；H0一C0系統(tǒng)；免疫組化英文摘要MeasuringHo一1inCordBloodofFuUTermSGAandItsExpressioninCordVesselsABSTRACTobjectiVe：Smallforgestationalage(SGA)，isbomnotonlywithlowbirthweight，growthretardation，high“skofasphyxiaduringdeliver)-intracranialhemorrhage，b

5、rainhypoXiainjury，barrierinmetabolismandcongenitaImalformation，10tjmestheperinatalmortalityofappropriateforgestationalage(AGA)，butalsowithpossibjlityofdelayeddeVelopmentinphysique，neuro—actionandbrainpower．Thereforeresearc

6、1ondiseasecause，prophylaxisandtrea“nentofSG

7、A，decreasingperin亂almortalityisofgIeatsignincance．Heme0xygenase(HO)isthespeed—limitenzymethatgeneratescalbonmonoxide(CO)，biIiVerdjnandFeinthecourseofhememetabolism，COisanewkindofneurotransmissionthatisinVolVedinadjustmentofmanykindsofphysiologicalfunctions：inducemen

8、tbloodvesselsrelaxationandinhibitionofplateletaggregation．BiljVerdincanreducetobilirubin．Theyarebothanti—oxidant，protectingcellagainstoxidatiVedamage．InvestigationshavealreadyshownthatHOcanincreasebIoodstreamintoutemsplacenta，acceIeratethefbrmationofbIoodvessels，and

9、protectplacentahistjocyte．Enoughbloodstreamintoutemsplacentaistheprerequisiteforhealthygrowthofaf色tus．Internalandextemalresearchesmainlvf-ocusonadultsor4英文摘要animalsbynow，whilenorelatedrepor七scanbe士、oundabouttherelationofH0一00systeminplacentatocauseofsmal】gestational

10、age．Thisdjssertatjon，bymeasuringHo—lactivityincordbloodoffhlltermhealthynewbornandSGA，percentageofHbC0inplasma，obserVingtheexpressionofH0一