資源描述：
《Pathogenesis and treatment of hepatitis e virus infection》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、GASTROENTEROLOGY2012;142:1388–1397PathogenesisandTreatmentofHepatitisEVirusInfectionHeinerWedemeyerSvenPischkeMichaelP.MannsDepartmentofGastroenterology,HepatologyandEndocrinologyandIFB-TxIntegratedResearchandTreatmentCenterTransplantation,HannoverMedicalSchool,Hannover,GermanyHepatitisEhasbeenc
2、onsideredtobeatravel-associ-tocynomolgusmacaques,whichledtohepatitis.AnRNAated,acute,self-limitingliverdiseasethatcausesful-specieswasidenti?edfromliversofinfectedanimalsandHEPATITISEVIRUSminanthepaticfailureinspeci?chigh-riskgroupsnamedhepatitisEvirus.4only.However,hepatitisEvirus(HEV)infection
3、canHEVisendemicinseveralAsianandAfricancountries,alsobeacquiredinindustrializedcountries—HEVge-wheretheprevalenceofHEVIgGantibodycouldbeasnotype3infectionisazoonosis,withpigsandrodentshighas50%.5IthasrecentlybeenestimatedthatHEVservingasanimalreservoirs.Inrecentyears,casesofinfectioncauses3mill
4、ionsymptomaticcasesofacutechronicHEVinfectionthatwereassociatedwithpro-hepatitisEeachyear,resultinginapproximately70,000gressiveliverdiseasehavebeendescribedinseveraldeathsworldwide.6Pregnantwomenandpatientswithcohortsofimmunocompromisedindividuals,includ-pre-existingchronicliverdiseasesareatapa
5、rticularriskofingrecipientsoforgantransplants.Thetopicofhep-fulminanthepaticfailureuponHEVinfection.Industri-atitisEisthereforere-emergingandhasraisedthealizedcountrieswereconsiderednonendemic,butanin-followingimportantquestions:whatistheriskforcreasingnumberofnon–travel-associatedcasesofHEVHEVi
6、nfectioninWesterncountries(eg,fromeatinginfectionshasbeenreportedinrecentyears,particularlyuncookedmeat)?Howfrequentlydoeschronichepa-inEurope.7–9ItisnotclearwhetherHEVincidenceratestitisEdevelopamonghumanimmunode?ciencyvi-arereallychangingorifmorecasesaredetectedthroughrus–infectedpatientsandre
7、cipientsoforgantrans-increasedsurveillance.7HepatitisEshouldalsobeconsid-plants?Whatarethetreatmentoptions?Whatistheeredinthedifferentialdiagnosisofdrug-inducedlivercurrentstatusofvaccinedevelopment?Whatdoweinjury,as3%ofpati
