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1、第42卷第6期哈爾濱醫(yī)科大學(xué)學(xué)報(bào)Vol.42,No.62008年12月JOURNALOFHARBINMEDICALUNIVERSITYDec.,2008625臨床研究磁共振單體素波譜在顳葉癲癇診斷中的應(yīng)用3夏清艷,劉鵬飛,王巍(哈爾濱醫(yī)科大學(xué)第一臨床醫(yī)學(xué)院磁共振科,黑龍江哈爾濱150001)[摘要]目的評(píng)價(jià)單體素氫質(zhì)子磁共振波譜(single2voxelhydrogenprotonmagneticresonancespectroscopy,SVS)診斷顳葉癲癇(temporallobeepilepsy,TLE)的價(jià)值。方法設(shè)對(duì)照組24例,顳葉癲癇組24例。應(yīng)用1.5T場(chǎng)
2、強(qiáng)的磁共振(magneticresonance,MR)設(shè)備分別對(duì)雙側(cè)海馬結(jié)構(gòu)(hippocampusformation,HF)行氫質(zhì)子波譜采集。比較TLE患側(cè)組、對(duì)側(cè)組及對(duì)照組各代謝物比值,并行致癇灶定側(cè)診斷。結(jié)果TLE患側(cè)組的N2乙酰天門冬氨酸/膽堿+肌酸[N2acetylasparte/(choline+creatine),NAA/(CHO+Cr)](0.46±0.08)、N2乙酰天門冬氨酸/肌酸(N2acetylas2parte/creatine,NAA/Cr)(0.92±0.23)下降,與對(duì)側(cè)組、對(duì)照組(分別為0.57±0.10、1.26±0.22;0.67±0
3、.08、1.47±0.10)差值有顯著性意義(t值分別為6.88、7.94,P<0.01)。結(jié)論SVS是一種無創(chuàng)性探測(cè)腦組織內(nèi)生化物質(zhì)改變的方法,對(duì)顳葉癲癇的定側(cè)診斷具有很大價(jià)值。[關(guān)鍵詞]單體素磁共振波譜;顳葉癲癇;診斷[中圖分類號(hào)]R742.1[文獻(xiàn)標(biāo)識(shí)碼]A[文章編號(hào)]1000-1905(2008)06-0625-04Diagnosisoftemporallobeepilepsywithsingle2voxelhydrogenprotonmagneticresonancespectroscopyXIAQing2yan,LIUPeng2fei,WANGWei(Dep
4、artmentofMagneticResonance,TheFirstClinicalCollege,HarbinMedicalUniversity,Harbin150001,China)Abstract:ObjectiveToinvestigatethevalueofsingle2voxelhydrogenprotonmagneticresonancespec2troscopy,SVS)indiagnosingpatientswithtemporallobeepilepsy(TLE).MethodsFourty2eightcases(24normal,24tempor
5、allobeepilepsy)experiencedsingle2voxelhydrogenprotonmagneticresonancespectroscopy(SVS).ThestudyofvolumeofSVSwaspalcedovertheanteriorhippocampusformation(HF)region,includingpartoftheheadandbodyofHFon1.5magneticresonancesystem.Themetabo2litedatafromSVSwasobtainedandtheratiosofN2acetylaspar
6、te/(choline+creatine)(NAA/CHO+Cr),andN2acetylasparte/creatine(NAA/Cr)wererecordedandcalculated.ResultsTheipsilateralepiletogeniczoneofpatientsshowedlowerratiosofNAA/(Cho+Cr)andNAA/Cr,andthedifferencescomparedwiththoseofthenormalgroupandcontralateralsubgroupwerestatisticallysignificant(t=
7、6188,P<0101andt=7194,P<0.01,respectively).ConclusionSVScanprovidebiochemicalandmetabolicinformationforthepreoperativeinvesitigationonpatientswithTLE.Keywords:magneticresonancespectroscopy;epilepsytemporallobe;diagnosis癲癇是臨床常見的一種病因復(fù)雜的反復(fù)發(fā)作的80%的頑固性癲癇患者的癲癇發(fā)作得到控制或完全[1]神經(jīng)系統(tǒng)疾病。發(fā)
