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《基于甲磺酰基的磺酰胺-氨醇作為催化醛的不對稱炔基化反應新配體(英文)》由會員上傳分享，免費在線閱讀，更多相關內(nèi)容在教育資源-天天文庫。
1、飪讓糍2O1OChineseJournalofCatalysisV_01．3lNo．9文章編號：0253．9837(2010)09—1098．05國際版DOI：101016／S1872-2067(10)60106—4研究論文：1098～1102基于甲磺?；幕酋０罚贝甲鳛榇呋┑牟粚ΨQ炔基化反應新配體金薇，黃永波，萬伯順中國科學院大連化學物理研究所，遼寧大連I16023摘要：以商業(yè)易得的(一)一麻黃堿、(+)一偽麻黃堿和各種手性氨醇為主要原料，經(jīng)過簡單的兩步反應，合成了一系列基于甲磺?；幕酋０芬话贝?SAA)配體，并將其用于催化苯乙
2、炔基鋅對醛的不塒稱加成反應．在沒有Ti(OiPr)等金屬試劑的條件下，配體表現(xiàn)出較好的不對稱誘導能力，取得了高達83％ee．關鍵詞：磺酰胺一氨醇配體；不對稱加成；炔基化反應；醛中圖分類號：0643文獻標識碼：AMethylsulfonyl--BasedSulfamide--AmineAlcoholasaLigandforEnantioselectiveAlkynylationofAldehydesJINWei，HUANGYongbo，WANBoshunDalianInstituteofChemicalP}{vsics，ChineseAc
3、ademyofSciences,Dalian116023，Liaoning,ChinaAbstract：Chiralmethylsulfonyl—basedsulfamide—aminealcohol(SAA)ligandsweresynthesizedfromcommerciallyavailablestartingma—terialsintwosimplesteps．Methylsulfonyl—basedSAAligandscatalyzedtheasymmetricalkynylationofvariousaldehydesus
4、ingalkynylzinctoprovidechiralpropargylalcoholswithmoderatetogoodenantioselectivityupto83％ee．Keywords：sulfamide—aminealcohol；enantioselectiveaddition；alkynylation；aldehydeThecatalyticenantiOselectiveadditionofterminala1methanesulfonylrTObasedSAAwerealsoeffectiveforthekyne
5、stoaldehydesisaveryusefulmethodforthesynthesisasymmetricalkynylationofcarbonylcompounds[36-38]．ofchiralpropargylalcohols，whichareimportantversatileInordertounderstandtheelectronicandstericeffectsofbuildingblocksofmanybiologicallyactivecompoundsandchiralSAAonasymmetricalk
6、ynylationofaldehydesandasnaturalproducts[1_4]．Inrecentyears，chiralligands，suchpartofextendingtheapplicationofourSAAligands，weasN—methylephedrine[5，6]，sulfonamidealcohol[7，8]，reportmethylsulfonyl(Ms)一basedSAAcatalyzedenanti—BIN0Landitsderivativesf9—121，havesuccessfullybee
7、noselectivealkynylationofaldehydesunderverymildcondi—usedinthisreaction．However，Ti(O-'Pr)4orothermetaltionswithoutusingmoisturesensitiveTi(O-'Pr)4andspeciesareusuallynecessaryinmostofthesecatalyticsys—Zn(OTf1，．terns[13～17]．Ontheotherhand[18—32]，efficientligandsthatcanbep
8、reparedfromcheapandeasilyavailablestarting1Experimentamaterialsinafewsyntheticstepsandthataredesignedfo
