腹膜后胃腸道外間質(zhì)瘤臨床病理診斷

《腹膜后胃腸道外間質(zhì)瘤臨床病理診斷》由會員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫。

1、腹膜后胃腸道外間質(zhì)瘤臨床病理診斷【關(guān)鍵詞】超微結(jié)構(gòu)【摘要】H的探討腹膜后胃腸道外間質(zhì)瘤的臨床病理特征及診斷與鑒別診斷。方法通過HE、免疫組化及電鏡觀察腹膜后胃腸道外間質(zhì)瘤2例并復(fù)習(xí)文獻(xiàn)。結(jié)果2例腹膜后胃腸道外間質(zhì)瘤患者均為男性，年齡分別29歲、35歲;腫瘤大小分別為9cmX6.5cmX5cm和35cmX30cmX22cm;腫瘤主要由梭形、上皮樣細(xì)胞組成，胞質(zhì)豐富，嗜酸或淡嗜酸，可見核仁。瘤細(xì)胞免疫表型:Vimentin、NSE、S?100蛋白、SMA、CD34、CD117、bcl?2均為陽性，desmin.CK和syn陰性。電鏡觀察顯示平滑肌瘤、神經(jīng)鞘瘤和神經(jīng)源性分化特征的特征

2、。結(jié)論本瘤具有平滑肌瘤、神經(jīng)鞘瘤和神經(jīng)源性分化的腫瘤，發(fā)牛于腹膜后罕見，其組織形態(tài)應(yīng)與平滑肌瘤、神經(jīng)鞘瘤、炎癥性肌纖維母細(xì)胞瘤等鑒別。關(guān)鍵詞腹膜灰腫瘤間質(zhì)瘤免疫組織化學(xué)超微結(jié)構(gòu)vPstyle=nTEXT-INDENT:24px”align=centei>RetroperitonealextragastrointestinalstromaltumorsWangZhuocai,LaiRiquan,HuangXiaorang,etal.

3、ter>GeneralHospitalofGuangzhouCommand,Guangzhou510010.[Abstract]ObjectiveToreporttheclinicopathologiccharacteristics,diagnosisanddifferentialdiagnosisintwocasesoftheretroperitonealextragastrointestinalstromaltumors.MethodsTwocasesoftheretroperitonealextra-gastrointestinalstromaltumorswasstud

4、iedbymeansofHEstain,immunohistochemistryandultrastiucturalobservationandliteraturerewiew.ResultsTwocasesoftheretroperitonealextragastrointestinalstromaltumorsweremale.Theywere29yeai*soldand35yearsold,respective!y.Theyrangedinsizefrom9cmX6.5cmX5cmto35cmX30cmX22cm.Thetumorcellsusuallyappeareda

5、scordsorweavecomposedofspindleorepithelioidcellswithlighteosinophiliccytoplasm.Nucleoliwereclear.ImmunohistochemicalassayshowedpositiveforVimentin,NSE,S-lOOproiein,SMA,CD34,bcl-2andCD117,butdesmin,CKandsynwerenegative.Thecharacteristicultrastructuralfeaturesshoweddifferentiationofleiomyoma,s

6、chwannomaandneurogenictumors.ConclusionTheretroperitonealextragastrointestinalstromaltumorwasaspecializedformofthegastrointestinalstromaltumorswithleiomyoma,schwannomaandneurogenictumors.ltoccuredrarelyinretroperitoneun.Differentialdiagnosticconsiderationsofretroperitonealextragastrointestin

7、alstromaltumorsshouldincludesmoothmuscletumor,neurilemmomaandinflamma-torymyofibroblastoma.Keywordsretroperitonealtumorstromaltumorimmunohistrochemistryultrastiucture胃腸道間質(zhì)瘤(Gastrointestinalstromaltumors,GIST)是不成熟梭形細(xì)胞或上皮樣細(xì)胞異彳f增殖形成腫瘤，常發(fā)生于胃腸道，腹膜厲較罕見;病