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1、Alzheimer’sDisease阿爾茨海默癥RonaldWilsonReagan羅納德·威爾遜·里根第40任（第49-50屆）美國總統(tǒng)president“IknowI'monmywaytothetwilight.Iknowthere'salwaysabrightdawnaheadoftheUnitedstates.Thankyou,myfriends.MayGodblessyouforever.”briefintroduction01Pathogeny＆Treatment03Clinicalmanifestatio
2、n02Other04Catalogbriefintroduction1What?Alzheimer'sdisease(AD)isaprogressiveneurodegenerativedisorder.臨床癥狀Clinicalsymptom記憶障礙dysmnesia失語aphasia失認(rèn)agnosia執(zhí)行功能障礙executivedysfunction癡呆dementiaThediseaseusuallybeginsafterage60,andriskgoesupwithage.TwotypesAlzheimer's
3、disease(AD)<65yearsoldseniledementia(SDAT)≥65yearsoldNameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualmentalillness.Hefoundabnormalclumps.Scientistsalsohavefoundotherbrainchangesinpeople
4、withAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.Clinicalmanifestation2ClinicalmanifestationⅠ期Ⅱ期Ⅲ期death1-3years2-10years8-12yearsMilddementiaModeratedementiaSeveredementiaMorewomenthanmen7:5~4:6Diseaseforupto10-20yearsDegradationo
5、fmemoryandcognitionWilliamUtermohlen的自畫像DegradationofmemoryandcognitionWilliamUtermohlenisanAmericanartist,in1995hewasdiagnosedwithAlzheimer'sdisease.Sincethen,hehasdecidedtotakeadvantageofthelimitedtimeavailabletoretainmemoryandbetterunderstandhimselfthroughsel
6、fportraits.Williaminsistedthe5NewYearpaintingsselfportrait,untilcompletelyforgottenhowtodraw.Fromtheuseofskilleddrawing,darkportrayalofvividfeatures,tothesamecolor,shapedeformation,selfportraitbecamemoreandmoreabstract(picturedabove).Degradationofmemoryandcognit
7、ion"theeffectsofAlzheimer'sdiseaseontherightparietallobeofthebrainareparticularlysevere,whichdirectlyaffectstheabilityofthebraintovisualizeanddeveloptheabilitytodrawpicturesofthebrain."saidDr.BruceMiller,aneurologist.Hisworkbecamemoreabstract,maybetheparietalfun
8、ctiondamaged,causingblindness.Whatkindofchangeshaveoccurredinthebrainsofpatientswithdementia,whichisnotyetfullyunderstoodbytheworld'sacademia.Pathogeny＆Treatment3Path
