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1、1081BACTERIOPHAGEAREPRESENTINTHESPUTUMOFPATIENTSUNUSUALLABORATORYFINDINGSINECHOVIRUS-11MENINGI-WITHBRONCHOPULMONARYPS.AERUGINOSAINFECTIONSTIS.C.MurrThomson,MararetC.Fisher,AdamadiaCarmenTe'edorandMichaelA.Zasloff(Spon.byJ.loS4Deforest,sakhS.'LonSp&.byAngeloM.DiGeorge)+Scul
2、man)GBB:NIAMDD,Bethesda,Maryland20205TempleUnive-hoolofMedici!e!St.Christopher'sHospitalAlthoughitisgenerallyappretiatedthatPs.aeruginosaforChildren,DepartmentofPediatrics,Philadelphia,Pa.specific-phagecanbeisolatedfromnaturalsourcesinwhichPs.Echovirus11(E-11)wasisolatedfr
3、omthecerebrospinalfluidaeruginosacanbefound,suchasseawaterandsewage,thepresence(CSF)of22childrenina1980summeroutbreakofmeningitis.ofphageatthesitesofPseudomonasinfectioninmanisnotSeventeen(77%)were<6mosold(range2wk-9yr).54%hadCSFcellwidelyrecognized.Usingroutinebacteriolog
4、icalprocedureswecounts>300/mm3and14%had>500/mm3(range0-2250).59%had250%showthatspecies-specificphagecanbeconsistentlyrecoveredpolymorphonuclears(P)and24%had>90%P.NonehadCSFglucosefromthesputumofpatientswithchronicPs.aeruginosabroncho-<40mg/dl;41%hadCSFprotein>45mg/dland6%h
5、ad>75mg/dl.Threepulmonaryinfections,including6patientswithcysticfibrosispatients(pts)hadentirelynorzalCSF.In86%peripheralWBCwasandonenonCFindividual.Ps.aeruginosaspecific-ph3gewerrf5000-15000/mm3;only3had>75%Pbut20%hadabsolutebandcountpresentinsputumatconcentrationsranging
6、between10to10>500/mm?Fourpts(<3mosold)hadrepeatCSFexams.Allhad2150viableparticledm1withasmanyas4differentphagestrainscells/mm3andthetwoyoungest(age2wk)stillhad>50%Pafterrecoveredfromasingleindividual.Ofthe16phageisolates,at1and3days.CSFfindingswerecomparedwithdatafromptswi
7、thleast12differentphagestrainscouldbeidentifiedbasedonbacterialmeningitis(B).Cellcount>500/mm3,glucose45mg/dl,bacterialhostsensitivityandelectronmicroscopicmorphology.andprotein>75mg/dlwerestatisticallyassociatedwithB.How-ItwouldappearthatPs.aeruginosaanditsphagecommonlyco
8、-ever,14%ofE-11ptshadatleastoneofthesefindingsand20%existatthesiteofhumanbronchopulmonary
