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1、Intervirology5:76-82(1975)Coronaviridae1D.A.J.Tyrrell,J.D.Almeida,C.H.Cunningham,W.R.Dowdle,M.S.Hofstad,K.McIntosh,M.Tajima,L.Ya.Zakstelskaya,B.C.Easterday,A.KapikianandR.W.BinghamAninformalproposalhasbeenmadetogrouptogetheranumberofrecentlyrecognizedvirusesundert
2、heheadofcoronaviruses[I],Theyaffectavarietyofhostscausingadiversityofdiseases,buttheyaregroupedtogethermainlybecausetheyhavesimilarelectronmicroscopicappearances,areether-labile,andprobablycontainRNA.However,rememberingthatinfluenzaandparainfluenzaviruseswereoncet
3、houghttobequitecloselyrelatedonsimilargrounds,muchofthegroupingshouldberegardedastentative.Nevertheless,murinestrains(MHV)areantigenicallyrelatedtosomehumanstrainsand,morphologically,human,avian,andmurinevirusesreplicateinasimilarway;itisthereforelikelythatatleast
4、someofthegroupingswillbeconfirmedbyfurtherinvestigation.ThereisnowsomemoredetailedinformationonthestructureoftheprototypevirusIBV(avianinfectiousbronchitisvirus),thestrikingfeaturesbeingthelargenumberofpeptidesandthelargesingleRNAstrand.Somestrainspossesshemagglut
5、ininandthereseemstobeahemagglutininreceptor-destroyingenzymewhichisnotaneuraminidase;alsothereisevidenceofaviralRNApolymerase.ThesefeaturesconfirmthatIBVisquitedistinctfromotherviruses.Westillhavenodetailedinformationaboutthebiochemicalcharacteristicsofitsnucleica
6、cid,theprocess1ReportoftheStudyGrouponCoronavirus,VertebrateVirusSubcommittee,InternationalCommitteeontheTaxonomyofViruses(ICTV).Beforetheproposalsbecomeofficial,theyrequireapprovaloftheICTVatitsnextmeetingtobeheldinMadrid,10September1975.Inthemeantime,thereportha
7、sbeenapprovedbyDr.H.G.Pereira,Chairman,VertebrateVirusSubcommittee;byDr.P.Wildy,Chairman,CoordinationSubcommittee:andbyDr.F.Fenner,President,ICTV.Received:May13,1975.Downloadedby:Univ.ofCaliforniaSantaBarbara128.111.121.42-3/6/20185:35:49AMTyrrellelat.77ofreplicat
8、ionorthelipidcompositionoftheenvelope.Allinall.thetimeisnowripeforcompletingthesebasicstudiesofIBVandcheckingwhetherthesamecharacteristicsarefoundintheo
