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1、VECTOR-BORNEANDZOONOTICDISEASESVolume12,Number6,2012aMaryAnnLiebert,Inc.DOI:10.1089/vbz.2011.0829AlphacoronavirusDetectedinBatsintheUnitedKingdomTomA.August,FionaMathews,andMilesA.NunnAbstractThisstudypresentsthe?rstrecordofcoronavirusinBritishbats.Alphacoronavirusstrainsweredetectedintwoofseven
2、batspecies,namelyMyotisnattereriandM.daubentonii.VirusprevalencewasparticularlyhighinthepreviouslyunrecognizedhostM.nattereri,whichcanliveincloseproximitytohumans.KeyWords:Chiroptera—Disease—DNAsequence—Epidemiology—Phylogeny—RT-PCR—Severeacuterespiratorysyndrome—UnitedKingdom—Virus—Zoonoses.Int
3、roductionbastellus,Myotisdaubentonii,M.nattereri,Plecotusauritus,Rhinolophusferrumequinum,andR.hipposideros.Zoonoticinfectionsoriginatinginwildlifeareasigni?cantthreattohumanhealth(Daszaketal.2000).MaterialsandMethodsInadditiontotheirrecognizedlinkwithrabiestransmission,batshavebeenidenti?edasth
4、ereservoirhostsofanumberSampleswerecollectedatsitesinsouthwestEnglandbe-ofvirusesthathavecauseddiseaseoutbreaksinthepasttween2006and2009.Asinglefecalpelletwascollectedfrom?decade(Wongetal.2007).TheBetacoronavirus,severeacuteeachbat,andeitherpreservedin250lLRNAlater(Appliedrespiratorysyndrome-rel
5、atedcoronavirus(SARS-CoV),Biosystems,Warrington,Cheshire,U.K.)orsnap-frozenonwhichprobablyoriginatedininsectivorousbats(Lietal.dryice.Sampleswerestoredat-80°Cuntilanalysis.Cotton2005),causedperhapsthemostsigni?cantoftheseoutbreaksbagsinwhichthebatswereheldweresterilizedbetweenin2002,resultingin8
6、096humancasesand774fatalitiesusebyautoclavingfollowedbysoakingin6%sodiumacross26countries(WorldHealthOrganization,2004).hypochlorite(domesticbleach)andwashingtopreventSubsequentsurveillancedetectedcoronavirus(CoV)speciesinbatsfromeverycontinenttheyinhabit,includingconti-nentalEurope(GenBanktaxon
7、omydata,January2011),butTable1.PrevalenceofCoronavirusinSevenSpeciescoronaviruseshavenotpreviouslybeenidenti?edinbatsinofBritishBatsbyReverseTranscriptase-PolymerasetheUnitedKingdom.ChainReactionAnalysisofFecalSamplesCoronav
