資源描述：
《冠狀病毒Coronavirusl論文-2009 Coronaviruses post-SARS_ update on replication and pathogenesis.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、REVIEWSCoronavirusespost-SARS:updateonreplicationandpathogenesisStanleyPerlmanandJasonNetlandAbstract
2、Althoughcoronaviruseswerefirstidentifiednearly60yearsago,theyonlyreceivednotorietyin2003whenoneoftheirmemberswasidentifiedastheaetiologicalagentofsevereacuterespiratorysynd
3、rome.Previouslytheseviruseswereknowntobeimportantagentsofrespiratoryandentericinfectionsofdomesticandcompanionanimalsandtocauseapproximately15%ofallcasesofthecommoncold.ThisReviewfocusesonrecentadvancesinourunderstandingofthemechanismsofcoronavirusreplication,interactionswi
4、ththehostimmuneresponseanddiseasepathogenesis.Italsohighlightstherecentidentificationofnumerousnovelcoronavirusesandthepropensityofthisvirusfamilytocrossspeciesbarriers.Coronaviruses,agenusintheCoronaviridaefamily(orderencodeanadditionalhaemagglutinin-esterase(HE)pro-Prothr
5、ombinaseMoleculethatcleavesNidovirales;fig.1),arepleomorphic,envelopedviruses.tein(fig.2a,b).TheHEprotein,whichmaybeinvolvedthrombin,therebyinitiatingtheCoronavirusesgainedprominenceduringthesevereacuteinvirusentryoregress,isnotrequiredforreplica-coagulationcascade.respirat
6、orysyndrome(SARS)outbreaksof2002–2003tion,butappearstobeimportantforinfectionofthe(ref.1).Theviralmembranecontainsthetransmembranenaturalhost5.(M)glycoprotein,thespike(S)glycoproteinandtheenve-Receptorsforseveralcoronaviruseshavebeeniden-lope(E)protein,andsurroundsadisorder
7、edorflexible,tified(TABLe1).Theprototypicalcoronavirus,mouseprobablyhelical,nucleocapsid2,3.Theviralmembraneishepatitisvirus(MHV),usesCEACAM1a,amemberofunusuallythick,probablybecausethecarboxy-terminalthemurinecarcinoembryonicantigenfamily,toenterregionoftheMproteinformsane
8、xtrainternallayer,ascells.Deletionofthisproteinmakesmiceresistanttorevealedbycryo-electrontomography2.Coronavirusesinfection6.Severalgroup1coronavirusesuseami-aredividedintothreegroups,andfurthersubdividednopeptidaseNtoadheretohostcells,consistentwithintosubgroups(TABLe1),b
9、asedinitiallyonserologic,andtheirrespiratoryandenterictracttropisms(reviewedinmore
