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1、64ESVP,ECVPandNSVPProceedings2015J.Comp.Path.2016,Vol.154,58e123MECHANISM-BASEDINVESTIGATIONINTOADAPTATIONMERSCORONAVIRUSINFECTIONINDROMEDARYTOOXIDATIVEACUTELUNGINJURYCAMELS,yy,yyG.Pellegrini*,D.WilliamsandA.Kipar*J.M.A.vandenBrand*,P.Wohlsein,V.StalinRaj*,*LaboratoryforAnimalModelPat
2、hology(LAMP),InstituteofVeterinaryS.L.Smits*,D.Schippers*,J.Segalesz,A.Bensaidz,yzxyPathology,VetSuisseFaculty,UniversityofZ€urich,SwitzerlandandCentreD.Solanes,A.Volz,T.Kuiken*,W.Baumgartner€,,yxforDrugSafetyScience,DepartmentofPharmacologyandTherapeutics,A.D.M.E.Osterhaus*,G.Sutter
3、andB.L.Haagmans*UniversityofLiverpool,UK*DepartmentofViroscience,ErasmusMedicalCenter,Rotterdam,TheyIntroduction:Acutelunginjury(ALI)remainsanimportantNetherlands,DepartmentofPathology,UniversityofVeterinaryMedicine,zsourceofmorbidityinhumanandveterinarypatients,andexper-Hannover,Germ
4、any,CentredeRecercaenSanitatAnimal(CReSA),ximentalanimalmodelsarekeytoolstoelucidateitspathophysio-Barcelona,SpainandInstituteforInfectiousDiseasesandZo€onoses,LMUlogicalmechanisms.WepresentherethemorphologicalandUniversityofMunich,Munich,Germanyfunctionalaspectsofoxidativepulmonaryin
5、juryinratsinducedIntroduction:MiddleEastrespiratorysyndromecoronavirus(MERS-bysmallthiourea-basedmolecules.Ratsexposedtoanormallyle-CoV)isanovelcoronaviruscausinganongoingoutbreakinman,some-thaldoseofthioureas,afterprioradministrationofasmalldose,timesresultinginsevereorevenfatalpneum
6、onia.Dromedarycamelsdeveloprapidadaptation(tolerance)andthosemechanismsarearesuggestedtobethereservoirhostforMERS-CoV.Infecteddrome-investigatedhere.dariesshedtheviruspredominantlyfromthenose,butshownooronlyMaterialsandMethods:Groupsofratsweretreatedwithamilddisease.Toelucidatethepath
7、ogenesisofMERS-CoVinfection,wephenylthioureacompoundtoinduceALIandadaptation,andas-inoculateddromedarycamelswithMERS-CoV.sessedbylightmicroscopyincludingimmunohistology,transmissionMaterialsandMethods:Four6-to8-month-olddromedaries,serolog-electronmicroscopy,glutathione(GSH)measuremen
8、ts,en
