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1、INDEXNote:Pagenumbersfollowedby“f”indicatefigures,and“t”indicatetables.AsubgenomicmessengerRNAsAntibody-dependentenhancementof(sgmRNAs),128–129infectivity(ADEI),270–27130-terminalAntiviralselection,CoVfunctionalroles,145–148enzymaticactivities,273structuralfeatures,142–145inhibitors,vacuolaracidi
2、fication,50-terminal273–274functionalroles,136–141p38MAPK,274structuralfeatures,133–136zoonoticcoronaviruses,128CCoronavirus(CoV)Cap-dependenttranslation,170–171eIF2αphosphorylationactivation,Cellularproteins,CoVreplication182–183BCoV,150ERstressandunfoldedproteinresponse,DDX5andDDX1,151180–181hn
3、RNPA1,149–150genomeorganizationandgeneexpressionPABP,150strategyTGEV,149–150discontinuousextension,170Circulatingvirulent-avirulentFCoVeIF4Fandthe43Spreinitiationhypothesis,203–204complex,169–170cis-actingRNAelements,CoVORFs,169cellularproteins,roleofsubgenomicminus-strandRNAs,170BCoV,150transcri
4、ptionregulatorysequencesDDX5andDDX1,151(TRS),169hnRNPA1,149–150HCoVPABP,150229E-infectedcells,170–171,184TGEV,149–150ORF,174–175Coronaviridaeclassification,128SARS-CoVandMERS-CoV,1686DIRNAsmA-modification,184definition,131–132MERS-CoV,168identificationandcharacterization,132MHV-infectedcells,184–
5、185leaderswitching,132mRNAtranslationgenomereplicationandtranscriptioncap-dependenttranslation,170–17130-50exoribonuclease,129–130IRES-mediatedtranslation,175–176ORF,131leakyscanningtranslationmechanism,RdRp,129–130internalORFs,174–175Sgminus-strandRNAs,130–131Nprotein-mediatedenhancement,transcr
6、iption-regulatingsequences177–178(TRSs),130–131poly(A)taillengthchanges,172nsp,128–129ribosomalframeshift,172–173ORF1aandORF1b,128–129ribosomalshuntingmechanism,174RNAelementsandgenomepackaging,structuralfeatures,184148–149upstreamORFs(uORF),176287288IndexCoronavirus(CoV)(Continued)Fviralenzymes,
7、171–172Felinecoronaviruses(FCoVs)viralUTRs,177accessorygenesandproteinsPERKactivation,182–183ORF3a,196PKRactivation,182–183ORF7a,196–197proteinsuppressors,translationORF3b,1967aprotein,180ORF7b,196–197eIF3f,180ORF3c,19