資源描述：
《冠狀病毒Coronavirusl論文-2000 Coronavirus-associated epizootic catarrhal enteritis in ferrets.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、526_530.QXD8/22/20052:44PMPage526Coronavirus-associatedepizooticcatarrhalenteritisinferretsEXOTICSBruceH.Williams,DVM,DACVP;MattiKiupel,MS,Drmedvet;KeithH.West,DVM,PhD;SMALLANIMALS/JamesT.Raymond,DVM,DACVP;ChristopherK.Grant,DVM,PhD;LawrenceT.Glickman
2、,VMD,DrPHterizedashavinghighmorbidityandlowmortalitywithinitialsignsoflethargy,inappetence,andvomit-Objective—Tocharacterizeclinicalsignsandlesionsing.Subsequently,profusebrightgreendiarrheawithandidentifytheetiologicagentassociatedwithepi-highmucusco
3、ntentdeveloped,oftenaffecting100%ofzooticcatarrhalenteritisindomesticferrets.ferretsineachfacility.DiseaseseverityinindividualsDesign—Cross-sectionalstudy.washighlyvariable;olderferretshadmoresevereAnimals—119ferretswithepizooticdiarrheaofpre-signs,wh
4、ereasyoungferretshadmildorsubclinicalsumedviralcauseand5controlferrets.infection.Sincethattime,thisdiseasehasbeendiag-Procedure—ClinicalrecordsandbiopsyornecropsynosedthroughouttheUnitedStatesandinseveralspecimensofferretswithpresumedepizooticothercou
5、ntries,affectingferretsinbreedingandrescuecatarrhalenteritiswerereviewed.Immunohisto-facilitiesaswellaspetferrets,resultinginsubstantialchemicalstainingforcoronavirusantigenwasper-economiclossandemotionaldistress.Thediseasewasformedonparaffin-embedded
6、tissuesfromapproxi-namedepizooticcatarrhalenteritis(ECE)afterstudymately10%ofaffectedferretstoidentifyviralantigenattheArmedForcesInstituteofPathologyonthebasisanddetermineitsdistribution.Transmissionelectronofsimilaritiestoadiarrhealdiseaseofmink(epi
7、zooticmicroscopywasperformedonfecalsamplesandsec-1catarrhalgastroenteritis).tionsofjejunum.VirusisolationstudiesaswellasimmunofluorescenttestsforothersimilarvirusesInECEofferrets,asinepizooticcatarrhalgas-wereperformed.troenteritisofmink,coronavirus-l
8、ikeparticleswereseeninfeces,andacombinationofatrophicandResults—Characteristicmicroscopiclesionsconsis-tentwithintestinalcoronavirusinfection(vacuolarinflammatoryentericlesionscharacteristicofchronicdegenerationandnecrosisofvillusenterocytes;v
