資源描述：
《冠狀病毒Coronavirusl論文-2006 Sialic acids as receptor determinants for coronaviruses.pdf》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、GlycoconjJ(2006)23:51–58DOI10.1007/s10719-006-5437-9MINIREVIEWSialicacidsasreceptordeterminantsforcoronavirusesChristelSchwegmann-We?els·GeorgHerrlerCSpringerScience+BusinessMedia,LLC2006AbstractAmongcoronaviruses,severalmembersareable1.Introductiontointeractwithsialicacids.Forbovinecoronav
2、irus(BCoV)andrelatedviruses,bindingtocellsurfacecomponentscon-Coronavirusesareadiversegroupofvirusesthatinfectdif-tainingN-acetyl-9-O-acetylneuraminicacidisessentialforferentmammalianandavianspecies.Theymostoftenaffectinitiationofaninfection.Thesevirusesresemblein?uenzatherespiratoryorintest
3、inaltract,butsomerepresentativesCvirusesbecausetheysharenotonlythereceptordetermi-mayalsoinfectothertissuesororgans.Coronavirusesarenant,butalsothepresenceofanacetylesterasethatreleasesclassi?edwithinthefamilyCoronaviridae,whichbelongsthe9-O-acetylgroupfromsialicacidandthusabolishesthetotheo
4、rderNidovirales.Thefamilyofcoronavirusescom-abilityoftherespectivesialoglycoconjugatetofunctionasprisestwogenera:CoronavirusandTorovirus.OurreviewareceptorforBCoV.Asinthecaseofin?uenzaviruses,willfocusonmembersofthegenusCoronavirus.Basedonthereceptor-destroyingenzymeofBCoVisbelievedtofa-anti
5、genicrelationshipandsequencesimilarity,coronavirusescilitatethespreadofvirusinfectionbyremovingreceptorareclassi?edintothreegroups(Table1).Thebeststudiedrep-determinantsfromthesurfaceofinfectedcellsandbypre-resentativeofgroup1coronavirusesisporcinetransmissibleventingtheformationofvirusaggre
6、gates.Anothercoron-gastroenteritisvirus(TGEV).Amonggroup2coronavirusesavirus,porcinetransmissiblegastroenteritisvirus(TGEV)mostinformationinmoleculartermsisavailableformousepreferentiallyrecognizesN-glycolylneuraminicacid.TGEVhepatitisvirus(MHV).However,morerepresentativeforthisdoesnotcontai
7、nareceptor-destroyingenzymeanddoesnotgroupisbovinecoronavirus(BCoV).Thehumancoronavirusdependonthesialicacidbindingactivityforinfectionofcul-associatedwithsevereacuterespiratorysyndrome(SARS-turedcells.However,bindingtosialicacidsisrequiredforCoV)i
