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1、中國婦幼健康研究2010年第2l卷第2期133新生兒低血糖病例腦損傷的多因素分析梁考文，宋海燕，王彬，安振存(北京市密云縣婦幼保健院兒科，北京101500)[摘要]目的探討新生兒低血糖病例腦損傷的相關因素。方法收集整理新生兒病房住院治療的低血糖患兒病例資料，分析低血糖患兒腦損傷的發(fā)病情況，對導致腦損傷的相關因素進行分析。結果腦損傷的發(fā)生率為54．4％，有神經(jīng)系統(tǒng)癥狀的低血糖患兒腦損傷發(fā)生率明顯增加；導致腦損傷的高危因素是長時間的低血糖(>12h)、伴有圍產(chǎn)期缺氧或感染。長時間低血糖患兒腦損傷發(fā)生率及重度腦損傷發(fā)生率分別為88．2％、58．8％，明顯高于短暫性低血糖者
2、(47．7％、5．8％)(=9．41，P<0．05；=32．06，P<0．01)；伴有圍產(chǎn)期缺氧或感染的患兒腦損傷發(fā)生率(77．8％、70．O％)分別高于無圍產(chǎn)期缺氧或感染者(46．1％、44．4％)，差異均有統(tǒng)計學意義(分別為8．08、6．44，均P<0．05)。結論長時間低血糖、圍產(chǎn)期缺氧或感染是發(fā)生低血糖腦損傷的高危因素，低血糖伴隨圍產(chǎn)期缺氧或感染會加重腦損傷。[關鍵詞]新生兒；低血糖；腦損傷；高危因素doi：10．3969／j．issn．1673—5293．2010．02．OO4[中圖分類號]R722[文獻標識碼]A[文章編號]1673—5293(2010)
3、02—0133—02Amulti-factorialanalysisofneonatalhypoglycemicbraininjuryUANGKao—wen，SONGHal-yan，WANGBin，ANZhen—cnn(DepartmentofPediatrics，MiyunCountyMaternalandChiMHealthHospitalofBeijing，Bering101500，China)[Abstract]ObjectiveToinvestigaterelatedfactorsofneonatalhypoglycemicbraininjury．Meth
4、odsTheclinicaldataofneonateswithhypoglycemiahospitalizedintheneonatalwardsofourhospitalwerecollected．Theincidenceofbraininjurywasinvestigatedandtherelatedfactorsofbraininjurywasanalyzed．ResultsTheincidenceofbraininjurywas54．4％．Inhypoglycemicneonateswithnervoussystemsymptoms，theincidenc
5、erateofbraininjurywassignificantlyhigher．Theriskfactorsthatcausedbraininjuryincludedprolongedhypoglycemia(>12h)，beingassociatedwithperinatalhypoxiaorinfection．Theincidenceratesofbraininjuryandseverebraininjuryinneonateswithprolongedhypoglycemiawere88．2％and58．8％respectively．whichwassign
6、ificantlyhigherthanthoseneonateswithtransienthypoglycemia(47．7％and5．8％respectively)，(=9．41，P<0．05；Xz=32．06，P<0．01)．Theincidencerateofbraininjuryintheneonateswithperinatalhypoxiaorinfection(77．8％，70．0％)werehigherthanthoseneonateswithoutperinatalhypoxiaorinfectiongroup(46．1％，44．4％)andthe
7、rewerestatisticallysignificantdifferences(=8．08and6．4respectively，bothP<0．05)．ConclusionProlongedhypoglycemia，perinatalhypoxiaandinfectionareriskfactorsofhypoglycemicbraininjury．Hypoglycemiaassociatedwithperinatalhypoxiaorinfectionwouldexacerbatethebraininjury．[Keywords]neonate；hypog
