鼠神經(jīng)生長因子對急性腦梗死患者血清超敏-C反應蛋白和神經(jīng)元特異性烯醇化酶水平的影響及療效觀察.pdf

《鼠神經(jīng)生長因子對急性腦梗死患者血清超敏-C反應蛋白和神經(jīng)元特異性烯醇化酶水平的影響及療效觀察.pdf》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在應用文檔-天天文庫。

1、·臨床研究·中國現(xiàn)代醫(yī)生2014年1月第52卷第2期鼠神經(jīng)生長因子對急性腦梗死患者血清超敏一c反應蛋白和神經(jīng)元特異性烯醇化酶水平的影響及療效觀察危英李海軍浙江省臺州市立醫(yī)院臺州學院醫(yī)學院附屬市立醫(yī)院神經(jīng)內(nèi)二科，浙江臺州318000【摘要]目的探討鼠神經(jīng)生長因子對急性腦梗死患者血清超敏一C反應蛋白(hs—CRP)和神經(jīng)元特異性烯醇化酶(NSE)水平的影響及療效觀察。方法72例急性腦梗死患者隨機分為觀察組和對照組。兩組均予以控制顱內(nèi)壓、血壓和血糖、抗血小板聚集、保護腦細胞及防治并發(fā)癥等治療。觀察組患者加用鼠神經(jīng)生長因子18g肌肉注射，1次／d，連

2、用2周。結(jié)果治療2周后，兩組患者血清hs—CRP和NSE水平均有明顯下降(P0．05)。結(jié)論鼠神經(jīng)生長因子治療急性腦梗死具有較好的療效及安全性，能明顯改善

3、患者的神經(jīng)功能及肢體運動功能，作用與其能降低血清Nhs—CRP和NSE水平密切相關(guān)。f關(guān)鍵詞】急性腦梗死；鼠神經(jīng)生長因子；超敏一c反應蛋白；神經(jīng)元特異性烯醇化酶【中圖分類號】R743【文獻標識碼】B[文章編號】1673—9701(2014)02—0030—03Theinfluenceandcurativeefectofmousenervegrowthfactoronhigh-sensitivityC-reactiveprotein(hs—CI)andneuron-specificenolasefNSE)inbloodserumofacutec

4、erebralinfarctionpatientsWElYingLIHaijunNo．2DepartmentofNerve，TaizhouMunicipalHospital，Zhejiang(TheAffiliatedMunicipalHospitalofTaizhouMed—icalCollege)，Taizhou318000，China[Abstract]ObjectiveTodiscusstheinfluenceandcurativeeffectofmousenervegrowthfactoronhigh——sensitivityC——

5、reactiveprotein(hs——CRP)andneuron-specificenolase(NSE)inbloodserumofacutecerebralinfarctionpatients．Methods72casesofacutecerebralinfarctionpatientsweredividedintoobservationgroupandcontrolgroup．Allpatientsweregivensymptomaticandsupportivetreatmentroutinelylike，intracranialp

6、ressurecontrol，bloodpressureandbloodsugarcontrol，plateletaggregation，braincellsprotection，preventionandtreatmentofcomplications，andetc．Thepatientsinobservationgroupweregivenmousenervegrowthfactor(18g)byintramuscularinjectiononetimedailyfor2weeks．ResultsAfter2weeks’medicaltr

7、eatment，theserumhs-CRPandNSElevelsofpatientsintwogroupsobviouslyweredeclinedthanbefore(P<0．05orP<0．01)，andthedecliningrateofobservationgroupwasmuchhigherthanthatincontrolgroup(尸<0．05)．Meanwhile，NHSSscoresofpatientsintwogroupsweredeclinedobviouslythanbefore(：0．05orP<0．01)，wh

8、iletheFMAscoreswereroseobviouslythanbefore(P<0．05orP<0．01)，anddeclin—ing／risingrat