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1、2013年第17卷第21期實(shí)用臨床醫(yī)藥雜志JournalofCIinica1MedicineinPractice·105·適形放療聯(lián)合替吉奧治療老年食管癌的療效分析翟沖亞,葉柯,楊成梁,葛紅,邱榮良,劉新菊(鄭州大學(xué)附屬腫瘤醫(yī)院放療科,河南鄭州,450008)摘要:目的探討適形放療聯(lián)合替吉奧治療老年食管癌患者的近期療效及安全性。方法將40例老年食管癌將患者隨機(jī)分為放療聯(lián)合同步替吉奧組(替吉奧組)和放療聯(lián)合同步DF方案組(DF組),每組20例,替吉奧組采用三維適形放療聯(lián)合替吉奧進(jìn)行治療,DF組采用三維適形放療聯(lián)合順鉑+
2、氟尿嘧啶+左亞葉酸鈣進(jìn)行治療,比較2組患者的治療完成情況、近期療效及不良反應(yīng)發(fā)生情況,并按照東部腫瘤協(xié)作組(E∞G)標(biāo)準(zhǔn)評(píng)價(jià)患者。結(jié)果替吉奧組完成同步放化療率顯著高于DF組,Ⅲ~Ⅳ級(jí)消化道反應(yīng)及白細(xì)胞減少發(fā)生率均顯著低于DF組,且ECOG評(píng)分改善顯著優(yōu)于DF組,差異均有統(tǒng)計(jì)學(xué)意義。而2組近期療效比較,差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論適形放療聯(lián)合替吉奧能有效改善老年食管癌患者的日常體能狀態(tài),提高生活質(zhì)量,且不良反應(yīng)輕,患者依從性好。關(guān)鍵詞:適形放療;替吉奧;食管癌;順鉑中圖分類號(hào):R735.1文獻(xiàn)標(biāo)志碼:A文章編號(hào):1672—2
3、353(2013)21—105—03DOI:10.7619/jcmp.201321030Analysisontherapeuticeffectofconformalradi0therapVcombinedwithS一1forelderlypatientswithesophagealcarcinomaZHAIChongya,YEKe,YANGChengliang,GEHong,QIURongliang,LIUXinju(TheAffiliatedTumorHospitalofZhengzhouUniversity,Zh
4、engzhou,Hen口,450008)ABSTRACT:ObjectiveToexploretheclinicaleffectandsafetyofconfoiTnalradiotherapycombinedwithS一1forelderlypatientswithesophagealcarcinoma.MethodsFortyelderlypatientswithesophagealcarcinomawererandomlydividedintoradiotherapyplusconcurrentS一1group
5、(S一1group)andradiotherapyplusconcurrentDFregimengroup(DFgroup).S一1groupW3Streat—edwithradiotherapyandS一1.whileDFgroupwithradiotherapypluscisplatin+fluorouracil+cal—ciumlevofolinate.Theconditionsoffinishingtreatment.clinicaleffectsandadversereactionswerecompared
6、intwogroups,anddailyperformancestatusofEasternCooperativeOncologyGroup(ECOG)wasevaluated.ResultsTherateofcompletingconcurrentchemoradiotherapyinS一1groupwasmarkedlyhigherthaninDFgroup,incidencesofdigestivereactionsatgradesIll—IVandleucopeniasignificantlylowertha
7、ninDFgroupandECOGscoreobviouslyhigherthaninDFgroup,withsignificantdifferences.Therewasnosignificantdifferencecomparedwithshort—termeffectsoftwogroups.ConclusionConforlTlalradiotherapycombinedwithS一1caneffectivelyamelioratedailyperformancestatusofelderlypatients
8、withesophagealcarcinoma,improvethequalityoflife,hasmildadversereactionsandgoodcompliance.KEYWORDS:conformalradiotherapy;S一1;esophagea1carcinoma;cisplatin隨著中國(guó)老齡化的加劇,7O歲以上歲老年食