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1、麻醉與鎮(zhèn)痛,·十一玉藥斜等2014~9YJ第4卷第17期地佐辛預(yù)防瑞芬太尼復(fù)合麻醉患者術(shù)后痛覺過敏的效果周紅艷湖北省崇陽縣人民醫(yī)院麻醉科,湖北崇陽437500【摘要】目的探討地佐辛預(yù)防瑞芬太尼復(fù)合麻醉患者術(shù)后痛覺過敏的臨床效果。方法收集2011年10月~2012年10月于我院行腹部手術(shù)ASAI~Ⅱ級患者72例,隨機(jī)分為觀察組與對照組各36例。兩組患者均給予靜脈復(fù)合麻醉,手術(shù)中持續(xù)微泵泵入丙泊酚與瑞芬太尼,并間斷注射維庫澳銨維持麻醉,觀察組于手術(shù)結(jié)束前給予地佐辛預(yù)防術(shù)后痛覺過敏,對照組不給予地佐辛。比較兩組患者術(shù)后拔管時(shí)間、自主呼吸及意識恢復(fù)時(shí)間,并比較術(shù)后疼痛評分。結(jié)果觀察組
2、患者在自主呼吸恢復(fù)時(shí)間、意識恢復(fù)時(shí)間、拔除氣管導(dǎo)管時(shí)間為(6.27±2.62)min、(8.34±2.43)rain、(9.38±3.08)min與對照組(5.89±2.21)min、(8.16±2.10)min、(9.21±3.12)min相比較差異無統(tǒng)計(jì)學(xué)意義(P>0.05o觀察組33例患者VRS評分為0分,對照組0例患者VRS評分為0分,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(t=l1.53,P<0.05o結(jié)論地佐辛在預(yù)防瑞芬太尼復(fù)合麻醉患者術(shù)后痛覺過敏方面效果明顯,可有效減輕患者疼痛感,利于術(shù)后恢復(fù),值得臨床推廣?!娟P(guān)鍵詞】地佐辛;瑞芬太尼復(fù)合麻醉;痛覺過敏;預(yù)防效果【中圖分類號
3、】R614【文獻(xiàn)標(biāo)識碼】B【文章編號】2095—0616(2014)17—94—03EffectsofdezocineonpreventingpostoperativehyperpathiainpatientsreceivingremifentanilcombinedanesthesiaZHOUHongyanDepartmentofAnesthesiology,ChongyangPeople’SHospital,Chongyang437500,China[Abstract]0bjectiveToinvestigatetheclinicaleffectsofdezocinein
4、preventingpostoperativehyperalgesiainthepatientsreceivingremifentanilcombinedanesthesia.MethodsSeventy—twopatientswithASAI-I1whoreceivedabdominalsurgeryinourhospitalfromOctober2011toOctober2012werecollectedandrandomlydividedintotheobservationgroupandthecontrolgroup,with36patientsineachgroup
5、.Bothgroupsweregivenintravenouscombinedanesthesia,intraoperativecontinuousmicropumpingofpropofolandremifentanilandintermittentinjectionofvecuroniumbromideinordertomaintainanesthesia.Theobservationgroupwasgivendezocinebeforetheendofsurgerytopreventpostoperativehyperpathiaandthecontrolgroupwa
6、snotgivendezocine.Thepostoperativeextubationtime,autonomousrespirationtime,consciousnessrecoverytimeandpainscoresofthetwogroupswerecompared.ResultsTheautonomousrespirationtime,consciousnessrecoverytimeandextubationtimeoftheobservationgroupwere(6.27±2.62)minutes,(8.34±2.43)minutesand(9.38±3.
7、08)minutes,whichweresignificantlydifferentfromthe(5.89±2.21)minutes,(8.16±2.1O)minutesand(9.21±3.12)minutesofthecontrolgroup(尸>0.05).Thirty-threepatientsoftheobservationgrouphadaVRSscoreof0andnoneofthecontrolgrouphadaVRSscoreof0,withstatisticallysignific