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1、醫(yī)學(xué)臨床研究2013年9月第30卷第9期JClinRes,Sep.2013,!!!·論著·全身麻醉下機(jī)械通氣對(duì)人體眼內(nèi)壓的影響周玉旺李杰孟翠萍吳為民(河北省廊坊市第四人民醫(yī)院麻醉科,河北廊坊065700)[摘要]【目的】探討全身麻醉下機(jī)械通氣對(duì)人體眼內(nèi)壓(IOP)的影響。【方法】選擇2012年5~l0月本院入院擇期行腹部及下肢手術(shù)患者100例,術(shù)前檢查患者均無心肺肝腎系統(tǒng)異常和眼部疾病史,采用連續(xù)硬膜外阻滯加氣管插管全身麻醉法。以麻醉機(jī)行間歇正壓通氣(IPPV)或不同壓力值的呼氣末正壓通氣(PEEP),記錄通氣前后中心靜脈壓(CVP)與IOP等指標(biāo)?!窘Y(jié)果
2、】IPPV時(shí),IOP從通氣前的(1.8土0.3)kPa升至通氣30rain后的(1.9±0.3)kPa;PEEP為5cmHzO及10cmH2O時(shí),lOP分別從通氣前的(2.0±0.3)kPa升至通氣30rain后的(2.6±0.2)kPa和通氣前的(2.0±0.4)kPa升至通氣30min后的(3.0±0.4)kPa,PEEP較IPPV對(duì)IOP造成的影響更大(Pd0.05),CVP與IOP具有正相關(guān)性(r一0.81,Pd0.05)?!窘Y(jié)論】對(duì)青光眼等眼內(nèi)疾病或眼外傷伴重要臟器損傷手術(shù)時(shí)若需機(jī)械通氣,最好選用IPPV,如必需用PEEP時(shí),呼氣末正壓勿大于10
3、cmHz0,以避免嚴(yán)重并發(fā)癥的發(fā)生。[關(guān)鍵詞]眼內(nèi)壓;麻醉,全身;呼吸,人工InfluenceofMechanicalVentilationOilIntraocularPressureinHumanBodyUnderGeneraIAn—esthesiaZHOUYu—wang,LIJie,MENGCui—ping,etal(DepartmentofAnesthesiology,eFourthPeople'sHospitalofLangfangCity,Hebei065700,China)[Abstract]【0ective】Toexploretheeffec
4、tofmechanicalventilationonintraocularpressure(1OP)inhu—manbody.[Methods1Atotalof100patientsundergoingelectivespinaloperationinourhospitalfromMay2012toOct.2O12wereselected.Inpreoperativeexamination,allpatientshadnoabnorma1heart,lung,1iverandkidneyfunctionandthehistoryofeyedisease.G
5、eneralanesthesiawithcontinuousepiduralblockandtra~cheaintubationwasperformed.Allpatientswereventilatedwithintermittentpositivepressureventilation(IP~PV)andpositiveendexpiratorypressure(PEEP)withdifferentpressures.Parameterssuchascentralvenouspressure(CVP)andIOPbeforeandafterventil
6、ationwererecorded.[ResultslwhenIPPV,theIOPincreasedfrom(1.8±0.3)kPabeforeventilationto(1.9±0.3)kPaafterventilation.IfPEEPwas5cmH2Oand10cmH2O,thelOPincreasedfrom(2.0±0.3)kPa30minbeforeventilationto(2.6±0.2)kPa30minaftervent~一1at~on,and(2.0±0.4)kPa30rainbeforeventilationto(3.0±0.4)k
7、Pa30minafterventilation。TheeffectofPEEPonIOPwasNoresignificant.CVPwaspositivelycorrelatedwithIOP(r一0.81,P<0.05).[Conclu—sionlIfmechanicalventilationisrequiredinthesurgeryofintraoculardiseasessuchasglaucomaoroculartrau—mawithimportantviscerainjury,IPPVisbesttobechosen.IfPEEPisneces
8、sary,thepositivepressureatendexpi