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1、t辱華^漣匕桑轟-⑩世界華人消化雜志2014年5J~j28Vq;22(15):2108—2115wcjd@wignet.comISSN1009—3079(print)ISSN2219—2859(online)臨床研究CLINICALRESEA_RCHGPC3與肝癌細(xì)胞增殖的相關(guān)性李海榮,黃蘭姍,陳罡,陸會(huì)平,馮振博■背景資料李海榮,黃蘭姍.陳罡,陸會(huì)平,馮振博,廣西醫(yī)科大學(xué)第一theeffectofGPC3knockdownonthegrowthof磷脂酰肌醇蛋附屬醫(yī)院病理科廣西壯族自治區(qū)南寧市530021HCCSMMC7721cells.白聚糖-3(glypi-李海榮,在讀碩士,主要
2、從事肝癌病理診斷與發(fā)生發(fā)展機(jī)制的can.3,GPC3)肝研究廣西科技攻關(guān)基金資助項(xiàng)目,Nos.10124001A一1,1298003-2RESULTS:GPC3expressionwassignificantly細(xì)胞癌(hepatocel—lularcarcinoma,—5correlatedwithKi.67Li(r=0.521,P=0.ooo).作者貢獻(xiàn)分布:此課題由李海榮與馮振博設(shè)計(jì):研究過(guò)程由李海HCC患者過(guò)度GPC3expressionwasrelatedtodifferentiation榮操作完成:研究所用新試劑由黃蘭姍與陸會(huì)平提供:數(shù)據(jù)分析表達(dá)的癌抗原之由李海榮與陳罡完成
3、:論文由李海榮撰寫(xiě):陳罡與馮振博審校degreeandvesselinvasionofHCCfr=0.287,一.初步展示出作通訊作者:馮振博教授,博士生導(dǎo)lJ幣,530021,廣西壯族自治區(qū)0.289;P=0.035,0.0341.Thecellproliferative為新的肝癌蛋白南寧市雙擁路22號(hào),廣西醫(yī)科大學(xué)第一附屬醫(yī)院病理科類標(biāo)志物的臨床activitywassignificantlyreducedintheGPC3一guanghul963@126com應(yīng)用價(jià)值.然而.電話:0771—5356534shRNAgroupcomparedwiththenegativecon-G
4、PC3對(duì)肝癌細(xì)收稿日期:2014—03—07修回日期:2014—04—03trolgroupandblankcontrolgroup(F45_38,P胞生長(zhǎng)的作用及接受日期:2014—04—09在線出版日期:2014—05—28具體機(jī)制報(bào)道不=0.000).一.本研究采用檢測(cè)臨床組織表達(dá)CONCLUSION:GPC3mayplayanimportant和體外功能實(shí)驗(yàn)CorrelationbetweenGPC3roleintheoccurrence,developmentandinva—的方法深入研究expressionandproliferationsionofHCC,mainlydu
5、etotheeffectonthepro—GPC3促進(jìn)HCC發(fā)生發(fā)展的分子機(jī)ofhepatoCe¨uIarcarcinomaliferationofHCCcells.制.探討GPC3在cells肝細(xì)胞癌增殖中⑥2014BaishidengPublishingGroupInc.Allrights的價(jià)值具有重要Hai-RongLi,Lan-ShanHuang,GangChen,reserved.的意義.Hui-PingLu,Zhen。BoFengKeyWords:Glypican一3:Ki-67;Hepatomacells;Pro-lirerationHal—RongLi,Lan—Shan
6、Huang,GangChen,Hui‘PingLu,Zhen-BoFeng,DepartmentofPathology,theFirstAf-filiatedHospitalofGuangxiMedicalUniversity,NanningLiHR,HuangLChenG,LuHFengZB.Correlation530021.GuangxiZhuangAutonomousRegion,ChinabetweenGPC3exPressionandProliferationofSupportedby:ScienceandTechnologyDevelopmentheDatoce1lu1a
7、rcarcinomacells.ShiiieHuarenXiaohuaProgramofGuangxiZhuangAutonomousRegion.Nos.Zazhi2014;22f151:21O8—2115URL:http://WWW.10l24001A一1and1298003.2。5wjgnet.com/1009—3079/22/2108.a(chǎn)spDoI:http://dx.doi.C0rresD0ndenceto:Zhen-BoFeng,P