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1、·3394··中醫(yī)·中西醫(yī)結(jié)合研究·基于因子分析的慢性乙型肝炎中醫(yī)證候特征研究王恩成,唐琳,王健,張磊,曹春輝,馮全生【摘要】目的探討四川地區(qū)慢性乙型肝炎中醫(yī)證候特征規(guī)律,為該病的中醫(yī)客觀化研究提供參考依據(jù)。方法采用橫斷面研究方法,根據(jù)課題組前期制定的慢性乙型肝炎病例表,記錄四川地區(qū)8家子課題臨床單位收集的1064例慢性乙型肝炎患者的四診信息,運(yùn)用因子分析的方法,探索慢性乙型肝炎證候特征規(guī)律。結(jié)果基于因子分析的1064例慢性乙型肝炎患者中醫(yī)證候研究共得到26個(gè)因子,結(jié)合專業(yè)知識(shí)及專家討論后最終合并為8個(gè)臨床因子組合證型,按解
2、釋的總方差由高到低依次為脾胃濕熱(15.725%)、肝腎陰虛(9.255%)、肝郁脾虛(8.939%)、肝郁化火(7.781%)、脾虛濕阻(7.055%)、瘀血阻滯(5.520%)、陽(yáng)虛(3.943%)、無證可辨(1.702%)。結(jié)論四川地區(qū)慢性乙型肝炎的主要證型為脾胃濕熱、肝腎陰虛、肝郁脾虛、肝郁化火、脾虛濕阻、瘀血阻滯、陽(yáng)虛、無證可辨?!娟P(guān)鍵詞】肝炎,乙型,慢性;證候;因子分析【中圖分類號(hào)】R749.94【文獻(xiàn)標(biāo)識(shí)碼】Adoi:10.3969/j.issn.1007—9572.2013.10.032王恩成,唐琳,王健,等
3、.基于因子分析的慢性乙型肝炎中醫(yī)證候特征研究[J].中國(guó)全科醫(yī)學(xué);2013,16(10):3394—3396.[WWW.ehinagp.net]TCMSyndromeCharacteristicsofChronicHepatitisB:AFactorAnalysisWANGEn—cheng,TANGLin,WANGJian,eta1.Sh如ngHospitalofTCM,Sh洳ng618400,China【Abstract】ObjectiveToexplorethecharacteristicofsyndromeofchro
4、nichepatitisB(CHB)inSichuanregion,SOastoprovideabasisforstudyonobjectificationofTCMsyndromeofCHB.MethodsTheCROSS—seetionalinvestigationwastaken,accordingtotheCHBcasesschedule,formulatedbyourresearchgrouppreviously,recordingtheinformationof1064chronichepatitisBpatie
5、ntscollectedbyfourdiagnosticmethodsfrom8clinicalunitsinSichuanregion.AndthefactoranalysismethodwasusedtOexplorethelawofsyndromecharacteristicsinCHB.ResultsBasedonthefactoranalysis,totally26factorswereobtainedfromthesyndromeresearchofallthe1064CHBpatients.Accordingt
6、otheprofessionalknowledgecombinedwithexpelsopinions,finally8factorsfulfillingtheclinicalpracticeweredetermined.Basedonthetotalvarianceexplained,theyrangedfromhightolowspleenandstomachdampness—heat(15.725%),yindeficiencyoftheliverandkidney(9.255%),spleendeficiencywi
7、thliver—qirestraint(8.939%),restrainedliver—qitransformingintofire(7.781%),spleendeficiencywithdampnessencumbrance(7.055%),staticbloodobstruction(5.520%),yangdeficiency(3.943%),andnodifferenti-atedsyndrome(1.702%).ConclusionThemainlysyndromeofCHBinSichuanregionares
8、pleenandstomachdampness—heat,yindeficiencyoftheliverandkidney,spleendeficiencywithliver—qirestraint,restrainedliver—qitransformingintofire,spleen