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1、DESCRIPTIONANDSOLUBILITYDescriptionandRelativeSolubilityofUSPandNFArticlesThe“description”and“solubility”statementspertainingtoanarticle(formerlyincludedintheindividualmonograph)aregeneralinnature.Theinformationisprovidedforthosewhouse,prepare,anddispensedrugs,solelytoin
2、dicatedescriptiveandsolubilitypropertiesofanarticlecomplyingwithmonographstandards.Thepropertiesarenotinthemselvesstandardsortestsforpurityeventhoughtheymayindirectlyassistinthepreliminaryevaluationoftheintegrityofanarticle.TasteandOdorOrganolepticcharacteristicsareindic
3、atedinmanyinstancesbecausetheymaybeusefulanddescriptivepropertiesofsubstances.However,theyarenotmeanttobeappliedastestsforidentifyingmaterials.Theinclusionofodorortasteamongotherdescriptivepropertiesmayaidinidentifyingthecausativeagentfollowingaccidentalexposuretoorconta
4、ctwithasubstance.Thisinformationisprovidedasawarningortomakeanindividualawareofsensationsthatmaybeencountered.Theuseofodorortasteasatestforidentificationorcontentisstronglydiscouraged.Thecharacteristicodorofavolatilesubstancebecomesapparentimmediatelyonopeningacontainero
5、fit.Theodormaybeagreeable(e.g.,PeppermintOil),unpleasant(e.g.,SulfurDioxide),orpotentiallyhazardousonprolongedexposure(e.g.,CoalTar).Moreover,anunexpectedodormaybeencounteredifthecharacteristicsofasubstancearenotknownorifacontainerisincorrectlylabeled.Consequently,contai
6、nersofsuchsubstancesshouldbeopenedcautiously,preferablyinawell-ventilatedfumehood.Acharacteristictasteorsensationproducedintheoralcavitylikewiseisapparentiftracesofresiduematerialsonfingersareinadvertentlybroughtintocontactwiththetongueoradjacentmucosaltissues.Solubility
7、Onlywhereaspecial,quantitativesolubilitytestisgivenintheindividualmonograph,andisdesignatedbyatestheading,isitatestforpurity.TheapproximatesolubilitiesofPharmacopeialandNationalFormularysubstancesareindicatedbythedescriptivetermsintheaccompanyingtable.Theterm“miscible”as
8、usedinthisPharmacopeiapertainstoasubstancethatyieldsahomogeneousmixturewhenmixedinanyproportionwiththed