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1、·3116·檢驗醫(yī)學(xué)與臨床2014年11月第11卷第22期LabMedClin,November2014,Vo1.11。No.22·論著·多種指標聯(lián)合檢測非小細胞肺癌的診斷價值劉敏,陳昌國,馬聰,趙強元,李娜,郭建巍,樂宇,賈坤(解放軍海軍總醫(yī)院檢驗科100048)【摘要】目的探討血清中神經(jīng)元特異性烯醇化酶(NSE)、癌胚抗原(CEA)、細胞角蛋白19片斷(cYFRA21—1)、乳酸脫氫酶(LDH)檢測在非小細胞肺癌臨床診斷中的價值。方法選擇病理確診的非小細胞肺癌患者86例作為研究對象,選取5O例非腫瘤肺部感染患者及6O例體檢健康者血清作對照,采用Beckman全自動免疫分析
2、系統(tǒng)檢測患者血清中CEA、CYFRA21-1水平,Roche4¨檢測患者血清中NSE水平,Beckman全自動生化儀(AU5821)檢測LDH水平,分析NSE、CEA、CYFRA21-1、LDH水平與非小細胞肺癌臨床特征之間的關(guān)系。結(jié)果(1)非小細胞肺癌患者血清中NSE、CEA、CYFRA21—1、LDH水平明顯高于非腫瘤肺部感染患者及健康者;(2)非小細胞肺癌組中NSE在未分型患者中水平明顯高于鱗狀細胞癌和腺癌患者,cYFRA21-1在鱗狀細胞癌中水平較高,CEA、LDH的水平差異不明顯;(3)NSE、CEA、CYFRA21-1聯(lián)合檢測陽性率高于NSE單獨檢測的陽性率。結(jié)論
3、血清NSE、CEA、CYFRA21-1水平聯(lián)合檢測有利于提高非小細胞肺癌的診斷率?!娟P(guān)鍵詞】非小細胞肺癌;腫瘤標志物;聯(lián)合檢測DOI:10.3969·/j.issn.1672-9455.2014.22.012文獻標志碼:A文章編號:1672—9455(2014)22—3116-03ThediagnosticvalueofthecombineddetectingofNSE,CEA,CYFRA21一l,LDHinnon—small—celllungcarcinomaLj【,Min,CHENChang~guo,MACong,ZHAoQiang—yuan,LJNa,GUOJian—w
4、ei,YUEYu,J,AKun(DepartmentofClinicalLabortaory,NavyGeneralHospitalBeijing100048,China)[Abstract]ObjectiveTostudytheelinicaldiagnosticvalueofserumneuron—specificenolase(NSE),carcino—embryonicantigen(CEA),cytokeratin19fragment(CYFRA21-1),lacticdehydrogenase(LDH)inpatientswithnonsmallcelllungc
5、ancer.MethodsAtotalof86patientswithnonsmallcelllungcarcinomawereselectedasobjectsinthisresearch,50patientswithnonetumorpulmonaryinfectionand40healthypersonswereselectedintocontrolgroup.CEA,CYFRA21—1levelsweredetectedbyautomaticimmunoassaysystemBeckman,thelevelofNSEwerede—tectedbyRoche411and
6、LDHweredetectedbyautomaticbiochemistrysystem.AnalyzedtherelationshipbetweenserumNSE,CEA,CYFRA21—1,LDH1evelsandtheclinica1featuresofnonsmal1cel1lungcancerpatients.ResultsTheserumNSE,CEA,CYFRA21—1,LDH1evelsinnonsmallcel1lungcarcinomapatientsweresignificanthigherthanthoseinpulmonaryinfectionpa
7、tientsandhealthypersons.TheNSElevelinpatientsthatsubtypenotdefinedwassignificanthigherthanthesquamous—cellcarcinomapatientsandadenocareinoma.CYFRA2l一1washighinsquamous-cellcarcinoma。nodifferenceswerefoundonthelevelsofCEAandLDH.Thedetectionrateofthecom—bi